Neurosteroid biosynthesis and function in the brain of domestic birds

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    It is now established that the brain and other nervous systems have the capability of form-ing steroids de novo, the so-called "neurosteroids." The pioneering discovery of Baulieu and his colleagues, using rodents, has opened the door to a new research field of "neuros-teroids." In contrast to mammalian vertebrates, little has been known regarding de novo neurosteroidogenesis in the brain of birds. We therefore investigated neurosteroid forma-tion and metabolism in the brain of quail, a domestic bird. Our studies over the past two decades demonstrated that the quail brain possesses cytochrome P450 side-chain cleav-age enzyme (P450scc), 3β-hydroxysteroid dehydrogenase/Δ54-isomerase (3β-HSD), 5β-reductase, cytochrome P45017α-hydroxylase/c17,20-lyase (P45017α,lyase), 17β-HSD, etc., and produces pregnenolone, progesterone, 5β-dihydroprogesterone (5β-DHP), 3β, 5β-tetrahydroprogesterone (3β,5β-THP), androstenedione, testosterone, and estradiol from cholesterol. Independently, Schlinger's laboratory demonstrated that the brain of zebra finch, a songbird, also produces various neurosteroids.Thus, the formation and metabolism of neurosteroids from cholesterol is now known to occur in the brain of birds. In addition, we recently found that the quail brain expresses cytochrome P450 and produces 7α-and 7β-hydroxypregnenolone, previously undescribed avian neurosteroids, from pregnenolone. This paper summarizes the advances made in our understanding of neurosteroid formation and metabolism in the brain of domestic birds.This paper also describes what are currently known about physiological changes in neurosteroid formation and biological functions of neurosteroids in the brain of domestic and other birds.

    Original languageEnglish
    Article numberArticle 37
    JournalFrontiers in Endocrinology
    Volume2
    Issue numberSEP
    DOIs
    Publication statusPublished - 2011

    Fingerprint

    Birds
    Neurotransmitter Agents
    Brain
    Quail
    Pregnenolone
    3-Hydroxysteroid Dehydrogenases
    Cholesterol
    Cytochrome Reductases
    Finches
    Isomerases
    Songbirds
    Lyases
    Androstenedione
    Equidae
    Cytochromes
    Mixed Function Oxygenases
    Cytochrome P-450 Enzyme System
    Nervous System
    Progesterone
    Vertebrates

    Keywords

    • Brain
    • Domestic birds
    • Neurosteroid function
    • Neurosteroidogenesis
    • Neurosteroids
    • Quail
    • Steroidogenic enzymes

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism

    Cite this

    Neurosteroid biosynthesis and function in the brain of domestic birds. / Tsutsui, Kazuyoshi.

    In: Frontiers in Endocrinology, Vol. 2, No. SEP, Article 37, 2011.

    Research output: Contribution to journalArticle

    @article{1ed584ca8ac64da3a80a1716ea2d2d52,
    title = "Neurosteroid biosynthesis and function in the brain of domestic birds",
    abstract = "It is now established that the brain and other nervous systems have the capability of form-ing steroids de novo, the so-called {"}neurosteroids.{"} The pioneering discovery of Baulieu and his colleagues, using rodents, has opened the door to a new research field of {"}neuros-teroids.{"} In contrast to mammalian vertebrates, little has been known regarding de novo neurosteroidogenesis in the brain of birds. We therefore investigated neurosteroid forma-tion and metabolism in the brain of quail, a domestic bird. Our studies over the past two decades demonstrated that the quail brain possesses cytochrome P450 side-chain cleav-age enzyme (P450scc), 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD), 5β-reductase, cytochrome P45017α-hydroxylase/c17,20-lyase (P45017α,lyase), 17β-HSD, etc., and produces pregnenolone, progesterone, 5β-dihydroprogesterone (5β-DHP), 3β, 5β-tetrahydroprogesterone (3β,5β-THP), androstenedione, testosterone, and estradiol from cholesterol. Independently, Schlinger's laboratory demonstrated that the brain of zebra finch, a songbird, also produces various neurosteroids.Thus, the formation and metabolism of neurosteroids from cholesterol is now known to occur in the brain of birds. In addition, we recently found that the quail brain expresses cytochrome P4507α and produces 7α-and 7β-hydroxypregnenolone, previously undescribed avian neurosteroids, from pregnenolone. This paper summarizes the advances made in our understanding of neurosteroid formation and metabolism in the brain of domestic birds.This paper also describes what are currently known about physiological changes in neurosteroid formation and biological functions of neurosteroids in the brain of domestic and other birds.",
    keywords = "Brain, Domestic birds, Neurosteroid function, Neurosteroidogenesis, Neurosteroids, Quail, Steroidogenic enzymes",
    author = "Kazuyoshi Tsutsui",
    year = "2011",
    doi = "10.3389/fendo.2011.00037",
    language = "English",
    volume = "2",
    journal = "Frontiers in Endocrinology",
    issn = "1664-2392",
    publisher = "Frontiers Media S. A.",
    number = "SEP",

    }

    TY - JOUR

    T1 - Neurosteroid biosynthesis and function in the brain of domestic birds

    AU - Tsutsui, Kazuyoshi

    PY - 2011

    Y1 - 2011

    N2 - It is now established that the brain and other nervous systems have the capability of form-ing steroids de novo, the so-called "neurosteroids." The pioneering discovery of Baulieu and his colleagues, using rodents, has opened the door to a new research field of "neuros-teroids." In contrast to mammalian vertebrates, little has been known regarding de novo neurosteroidogenesis in the brain of birds. We therefore investigated neurosteroid forma-tion and metabolism in the brain of quail, a domestic bird. Our studies over the past two decades demonstrated that the quail brain possesses cytochrome P450 side-chain cleav-age enzyme (P450scc), 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD), 5β-reductase, cytochrome P45017α-hydroxylase/c17,20-lyase (P45017α,lyase), 17β-HSD, etc., and produces pregnenolone, progesterone, 5β-dihydroprogesterone (5β-DHP), 3β, 5β-tetrahydroprogesterone (3β,5β-THP), androstenedione, testosterone, and estradiol from cholesterol. Independently, Schlinger's laboratory demonstrated that the brain of zebra finch, a songbird, also produces various neurosteroids.Thus, the formation and metabolism of neurosteroids from cholesterol is now known to occur in the brain of birds. In addition, we recently found that the quail brain expresses cytochrome P4507α and produces 7α-and 7β-hydroxypregnenolone, previously undescribed avian neurosteroids, from pregnenolone. This paper summarizes the advances made in our understanding of neurosteroid formation and metabolism in the brain of domestic birds.This paper also describes what are currently known about physiological changes in neurosteroid formation and biological functions of neurosteroids in the brain of domestic and other birds.

    AB - It is now established that the brain and other nervous systems have the capability of form-ing steroids de novo, the so-called "neurosteroids." The pioneering discovery of Baulieu and his colleagues, using rodents, has opened the door to a new research field of "neuros-teroids." In contrast to mammalian vertebrates, little has been known regarding de novo neurosteroidogenesis in the brain of birds. We therefore investigated neurosteroid forma-tion and metabolism in the brain of quail, a domestic bird. Our studies over the past two decades demonstrated that the quail brain possesses cytochrome P450 side-chain cleav-age enzyme (P450scc), 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD), 5β-reductase, cytochrome P45017α-hydroxylase/c17,20-lyase (P45017α,lyase), 17β-HSD, etc., and produces pregnenolone, progesterone, 5β-dihydroprogesterone (5β-DHP), 3β, 5β-tetrahydroprogesterone (3β,5β-THP), androstenedione, testosterone, and estradiol from cholesterol. Independently, Schlinger's laboratory demonstrated that the brain of zebra finch, a songbird, also produces various neurosteroids.Thus, the formation and metabolism of neurosteroids from cholesterol is now known to occur in the brain of birds. In addition, we recently found that the quail brain expresses cytochrome P4507α and produces 7α-and 7β-hydroxypregnenolone, previously undescribed avian neurosteroids, from pregnenolone. This paper summarizes the advances made in our understanding of neurosteroid formation and metabolism in the brain of domestic birds.This paper also describes what are currently known about physiological changes in neurosteroid formation and biological functions of neurosteroids in the brain of domestic and other birds.

    KW - Brain

    KW - Domestic birds

    KW - Neurosteroid function

    KW - Neurosteroidogenesis

    KW - Neurosteroids

    KW - Quail

    KW - Steroidogenic enzymes

    UR - http://www.scopus.com/inward/record.url?scp=84874376570&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84874376570&partnerID=8YFLogxK

    U2 - 10.3389/fendo.2011.00037

    DO - 10.3389/fendo.2011.00037

    M3 - Article

    C2 - 22645509

    AN - SCOPUS:84874376570

    VL - 2

    JO - Frontiers in Endocrinology

    JF - Frontiers in Endocrinology

    SN - 1664-2392

    IS - SEP

    M1 - Article 37

    ER -