Neurosteroid biosynthesis

Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides

Jean Luc Do Rego, Jae Young Seong, Delphine Burel, Jerôme Leprince, Van Luu-The, Kazuyoshi Tsutsui, Marie Christine Tonon, Georges Pelletier, Hubert Vaudry

    Research output: Contribution to journalArticle

    217 Citations (Scopus)

    Abstract

    Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids are also involved in the control of a number of behavioral, neuroendocrine and metabolic processes such as regulation of food intake, locomotor activity, sexual activity, aggressiveness, anxiety, depression, body temperature and blood pressure. In this article, we summarize the current knowledge regarding the existence, neuroanatomical distribution and biological activity of the enzymes responsible for the biosynthesis of neurosteroids in the brain of vertebrates, and we review the neuronal mechanisms that control the activity of these enzymes. The observation that the activity of key steroidogenic enzymes is finely tuned by various neurotransmitters and neuropeptides strongly suggests that some of the central effects of these neuromodulators may be mediated via the regulation of neurosteroid production.

    Original languageEnglish
    Pages (from-to)259-301
    Number of pages43
    JournalFrontiers in Neuroendocrinology
    Volume30
    Issue number3
    DOIs
    Publication statusPublished - 2009 Aug

    Fingerprint

    Neuropeptides
    Neurotransmitter Agents
    Enzymes
    Appetite Regulation
    Locomotion
    Body Temperature
    Sexual Behavior
    Vertebrates
    Anxiety
    Steroids
    Depression
    Blood Pressure
    Neurons
    Brain

    Keywords

    • Biological activities
    • Central nervous system
    • Neuroanatomical distribution
    • Neuropeptides
    • Neurosteroids
    • Neurotransmitters
    • Regulation
    • Steroidogenic enzymes

    ASJC Scopus subject areas

    • Endocrine and Autonomic Systems

    Cite this

    Neurosteroid biosynthesis : Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides. / Do Rego, Jean Luc; Seong, Jae Young; Burel, Delphine; Leprince, Jerôme; Luu-The, Van; Tsutsui, Kazuyoshi; Tonon, Marie Christine; Pelletier, Georges; Vaudry, Hubert.

    In: Frontiers in Neuroendocrinology, Vol. 30, No. 3, 08.2009, p. 259-301.

    Research output: Contribution to journalArticle

    Do Rego, JL, Seong, JY, Burel, D, Leprince, J, Luu-The, V, Tsutsui, K, Tonon, MC, Pelletier, G & Vaudry, H 2009, 'Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides', Frontiers in Neuroendocrinology, vol. 30, no. 3, pp. 259-301. https://doi.org/10.1016/j.yfrne.2009.05.006
    Do Rego, Jean Luc ; Seong, Jae Young ; Burel, Delphine ; Leprince, Jerôme ; Luu-The, Van ; Tsutsui, Kazuyoshi ; Tonon, Marie Christine ; Pelletier, Georges ; Vaudry, Hubert. / Neurosteroid biosynthesis : Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides. In: Frontiers in Neuroendocrinology. 2009 ; Vol. 30, No. 3. pp. 259-301.
    @article{32652ade91904193a28ec8dc52e2e3d3,
    title = "Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides",
    abstract = "Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids are also involved in the control of a number of behavioral, neuroendocrine and metabolic processes such as regulation of food intake, locomotor activity, sexual activity, aggressiveness, anxiety, depression, body temperature and blood pressure. In this article, we summarize the current knowledge regarding the existence, neuroanatomical distribution and biological activity of the enzymes responsible for the biosynthesis of neurosteroids in the brain of vertebrates, and we review the neuronal mechanisms that control the activity of these enzymes. The observation that the activity of key steroidogenic enzymes is finely tuned by various neurotransmitters and neuropeptides strongly suggests that some of the central effects of these neuromodulators may be mediated via the regulation of neurosteroid production.",
    keywords = "Biological activities, Central nervous system, Neuroanatomical distribution, Neuropeptides, Neurosteroids, Neurotransmitters, Regulation, Steroidogenic enzymes",
    author = "{Do Rego}, {Jean Luc} and Seong, {Jae Young} and Delphine Burel and Jer{\^o}me Leprince and Van Luu-The and Kazuyoshi Tsutsui and Tonon, {Marie Christine} and Georges Pelletier and Hubert Vaudry",
    year = "2009",
    month = "8",
    doi = "10.1016/j.yfrne.2009.05.006",
    language = "English",
    volume = "30",
    pages = "259--301",
    journal = "Frontiers in Neuroendocrinology",
    issn = "0091-3022",
    publisher = "Academic Press Inc.",
    number = "3",

    }

    TY - JOUR

    T1 - Neurosteroid biosynthesis

    T2 - Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides

    AU - Do Rego, Jean Luc

    AU - Seong, Jae Young

    AU - Burel, Delphine

    AU - Leprince, Jerôme

    AU - Luu-The, Van

    AU - Tsutsui, Kazuyoshi

    AU - Tonon, Marie Christine

    AU - Pelletier, Georges

    AU - Vaudry, Hubert

    PY - 2009/8

    Y1 - 2009/8

    N2 - Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids are also involved in the control of a number of behavioral, neuroendocrine and metabolic processes such as regulation of food intake, locomotor activity, sexual activity, aggressiveness, anxiety, depression, body temperature and blood pressure. In this article, we summarize the current knowledge regarding the existence, neuroanatomical distribution and biological activity of the enzymes responsible for the biosynthesis of neurosteroids in the brain of vertebrates, and we review the neuronal mechanisms that control the activity of these enzymes. The observation that the activity of key steroidogenic enzymes is finely tuned by various neurotransmitters and neuropeptides strongly suggests that some of the central effects of these neuromodulators may be mediated via the regulation of neurosteroid production.

    AB - Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids are also involved in the control of a number of behavioral, neuroendocrine and metabolic processes such as regulation of food intake, locomotor activity, sexual activity, aggressiveness, anxiety, depression, body temperature and blood pressure. In this article, we summarize the current knowledge regarding the existence, neuroanatomical distribution and biological activity of the enzymes responsible for the biosynthesis of neurosteroids in the brain of vertebrates, and we review the neuronal mechanisms that control the activity of these enzymes. The observation that the activity of key steroidogenic enzymes is finely tuned by various neurotransmitters and neuropeptides strongly suggests that some of the central effects of these neuromodulators may be mediated via the regulation of neurosteroid production.

    KW - Biological activities

    KW - Central nervous system

    KW - Neuroanatomical distribution

    KW - Neuropeptides

    KW - Neurosteroids

    KW - Neurotransmitters

    KW - Regulation

    KW - Steroidogenic enzymes

    UR - http://www.scopus.com/inward/record.url?scp=67849097168&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=67849097168&partnerID=8YFLogxK

    U2 - 10.1016/j.yfrne.2009.05.006

    DO - 10.1016/j.yfrne.2009.05.006

    M3 - Article

    VL - 30

    SP - 259

    EP - 301

    JO - Frontiers in Neuroendocrinology

    JF - Frontiers in Neuroendocrinology

    SN - 0091-3022

    IS - 3

    ER -