Neurosteroid biosynthesis in the brain of amphibians

Hubert Vaudry, Jean Luc Do Rego, Delphine Burel, Van Luu-The, Georges Pelletier, David Vaudry, Kazuyoshi Tsutsui

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Amphibians have been widely used to investigate the synthesis of biologically active steroids in the brain and the regulation of neurosteroid production by neurotransmitters and neuropeptides. The aim of the present review is to summarize the current knowl- edge regarding the neuroanatomical distribution and biochemical activity of steroidogenic enzymes in the brain of anurans and urodeles. The data accumulated over the past two decades demonstrate that discrete populations of neurons and/or glial cells in the frog and newt brains express the major steroidogenic enzymes and are able to synthesize de novo a number of neurosteroids from cholesterol/pregnenolone. Since neurosteroidogen- esis has been conserved during evolution from amphibians to mammals, it appears that neurosteroids must play important physiological functions in the central nervous system of vertebrates.

    Original languageEnglish
    Article numberArticle 79
    JournalFrontiers in Endocrinology
    Volume2
    Issue numberNOV
    DOIs
    Publication statusPublished - 2011

    Fingerprint

    Amphibians
    Neurotransmitter Agents
    Brain
    Salamandridae
    Pregnenolone
    Enzymes
    Neuropeptides
    Neuroglia
    Anura
    Vertebrates
    Mammals
    Central Nervous System
    Steroids
    Cholesterol
    Neurons
    Population

    Keywords

    • Amphibians
    • Brain
    • Neurosteroids
    • Steroidogenic enzymes

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism

    Cite this

    Vaudry, H., Rego, J. L. D., Burel, D., Luu-The, V., Pelletier, G., Vaudry, D., & Tsutsui, K. (2011). Neurosteroid biosynthesis in the brain of amphibians. Frontiers in Endocrinology, 2(NOV), [Article 79]. https://doi.org/10.3389/fendo.2011.00079

    Neurosteroid biosynthesis in the brain of amphibians. / Vaudry, Hubert; Rego, Jean Luc Do; Burel, Delphine; Luu-The, Van; Pelletier, Georges; Vaudry, David; Tsutsui, Kazuyoshi.

    In: Frontiers in Endocrinology, Vol. 2, No. NOV, Article 79, 2011.

    Research output: Contribution to journalArticle

    Vaudry, H, Rego, JLD, Burel, D, Luu-The, V, Pelletier, G, Vaudry, D & Tsutsui, K 2011, 'Neurosteroid biosynthesis in the brain of amphibians', Frontiers in Endocrinology, vol. 2, no. NOV, Article 79. https://doi.org/10.3389/fendo.2011.00079
    Vaudry H, Rego JLD, Burel D, Luu-The V, Pelletier G, Vaudry D et al. Neurosteroid biosynthesis in the brain of amphibians. Frontiers in Endocrinology. 2011;2(NOV). Article 79. https://doi.org/10.3389/fendo.2011.00079
    Vaudry, Hubert ; Rego, Jean Luc Do ; Burel, Delphine ; Luu-The, Van ; Pelletier, Georges ; Vaudry, David ; Tsutsui, Kazuyoshi. / Neurosteroid biosynthesis in the brain of amphibians. In: Frontiers in Endocrinology. 2011 ; Vol. 2, No. NOV.
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