Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication

Yan Chao Li; Wan Zhu Bai; Norio Hirano; Tsuyako Hayashida; Takahide Taniguchi; Yoichi Sugita; Koujiro Tohyama; Tsutomu Hashikawa

doi:10.1002/cne.23171

Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication

Yan Chao Li^*, Wan Zhu Bai, Norio Hirano, Tsuyako Hayashida, Takahide Taniguchi, Yoichi Sugita, Koujiro Tohyama, Tsutomu Hashikawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

106 Citations (Scopus)

Abstract

Swine hemagglutinating encephalomyelitis virus (HEV) has been shown to have a capability to propagate via neural circuits to the central nervous system after peripheral inoculation, resulting in acute deadly encephalomyelitis in natural host piglets as well as in experimental younger rodents. This study has systematically examined the assembly and dissemination of HEV 67N in the primary motor cortex of infected rats and provides additional evidence indicating that membranous-coating-mediated endo-/exocytosis can be used by HEV for its transsynaptic transfer. In addition, our results suggested that this transsynaptic pathway could adapted for larger granular materials, such as viruses. These findings should help in understanding the mechanisms underlying coronavirus infections as well as the intercellular exchanges occurring at the synaptic junctions.

Original language	English
Pages (from-to)	203-212
Number of pages	10
Journal	Journal of Comparative Neurology
Volume	521
Issue number	1
DOIs	https://doi.org/10.1002/cne.23171
Publication status	Published - 2013 Jan 1
Externally published	Yes

Keywords

Coronavirus
Neurons
Transsynaptic transfer
Virus replication

ASJC Scopus subject areas

Neuroscience(all)

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10.1002/cne.23171

Cite this

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title = "Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication",

abstract = "Swine hemagglutinating encephalomyelitis virus (HEV) has been shown to have a capability to propagate via neural circuits to the central nervous system after peripheral inoculation, resulting in acute deadly encephalomyelitis in natural host piglets as well as in experimental younger rodents. This study has systematically examined the assembly and dissemination of HEV 67N in the primary motor cortex of infected rats and provides additional evidence indicating that membranous-coating-mediated endo-/exocytosis can be used by HEV for its transsynaptic transfer. In addition, our results suggested that this transsynaptic pathway could adapted for larger granular materials, such as viruses. These findings should help in understanding the mechanisms underlying coronavirus infections as well as the intercellular exchanges occurring at the synaptic junctions.",

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AU - Li, Yan Chao

AU - Bai, Wan Zhu

AU - Hirano, Norio

AU - Hayashida, Tsuyako

AU - Taniguchi, Takahide

AU - Sugita, Yoichi

AU - Tohyama, Koujiro

AU - Hashikawa, Tsutomu

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Swine hemagglutinating encephalomyelitis virus (HEV) has been shown to have a capability to propagate via neural circuits to the central nervous system after peripheral inoculation, resulting in acute deadly encephalomyelitis in natural host piglets as well as in experimental younger rodents. This study has systematically examined the assembly and dissemination of HEV 67N in the primary motor cortex of infected rats and provides additional evidence indicating that membranous-coating-mediated endo-/exocytosis can be used by HEV for its transsynaptic transfer. In addition, our results suggested that this transsynaptic pathway could adapted for larger granular materials, such as viruses. These findings should help in understanding the mechanisms underlying coronavirus infections as well as the intercellular exchanges occurring at the synaptic junctions.

AB - Swine hemagglutinating encephalomyelitis virus (HEV) has been shown to have a capability to propagate via neural circuits to the central nervous system after peripheral inoculation, resulting in acute deadly encephalomyelitis in natural host piglets as well as in experimental younger rodents. This study has systematically examined the assembly and dissemination of HEV 67N in the primary motor cortex of infected rats and provides additional evidence indicating that membranous-coating-mediated endo-/exocytosis can be used by HEV for its transsynaptic transfer. In addition, our results suggested that this transsynaptic pathway could adapted for larger granular materials, such as viruses. These findings should help in understanding the mechanisms underlying coronavirus infections as well as the intercellular exchanges occurring at the synaptic junctions.

KW - Coronavirus

KW - Neurons

KW - Transsynaptic transfer

KW - Virus replication

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Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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