Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication

Yan Chao Li, Wan Zhu Bai, Norio Hirano, Tsuyako Hayashida, Takahide Taniguchi, Yoichi Sugita, Koujiro Tohyama, Tsutomu Hashikawa

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Swine hemagglutinating encephalomyelitis virus (HEV) has been shown to have a capability to propagate via neural circuits to the central nervous system after peripheral inoculation, resulting in acute deadly encephalomyelitis in natural host piglets as well as in experimental younger rodents. This study has systematically examined the assembly and dissemination of HEV 67N in the primary motor cortex of infected rats and provides additional evidence indicating that membranous-coating-mediated endo-/exocytosis can be used by HEV for its transsynaptic transfer. In addition, our results suggested that this transsynaptic pathway could adapted for larger granular materials, such as viruses. These findings should help in understanding the mechanisms underlying coronavirus infections as well as the intercellular exchanges occurring at the synaptic junctions.

Original languageEnglish
Pages (from-to)203-212
Number of pages10
JournalJournal of Comparative Neurology
Volume521
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1
Externally publishedYes

Keywords

  • Coronavirus
  • Neurons
  • Transsynaptic transfer
  • Virus replication

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication'. Together they form a unique fingerprint.

  • Cite this

    Li, Y. C., Bai, W. Z., Hirano, N., Hayashida, T., Taniguchi, T., Sugita, Y., Tohyama, K., & Hashikawa, T. (2013). Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication. Journal of Comparative Neurology, 521(1), 203-212. https://doi.org/10.1002/cne.23171