Neurovascular coupling in the human somatosensory cortex: A single trial study

Mitsuru Kikuchi, Kiyomi Shitamichi, Sanae Ueno, Yuko Yoshimura, Gerard B. Remijn, Kikuko Nagao, Toshio Munesue, Koichi Iiyama, Tsunehisa Tsubokawa, Yasuhiro Haruta, Yoshihiro Inoue, Katsumi Watanabe, Takanori Hashimoto, Haruhiro Higashida, Yoshio Minabe

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Oscillations in the higher frequency range are closely related to regional brain hemodynamic changes. Here we investigated this neurovascular coupling in humans in response to electrical stimulation of the right median nerve. In a single-trial study, we simultaneously recorded hemodynamic fluctuations in the somatosensory cortex by near infrared spectroscopy and brain neuronal oscillations by whole-head magnetoencephalography (MEG). The results from six volunteers showed that neural fluctuations at β or γ-band power were correlated with hemodynamic fluctuation during stimulus conditions. These correlations were prominent with a time delay of 5-7 s. This study provides new direct evidence that hemodynamic onset lags specific neural oscillations in the order of seconds in human awake conditions using noninvasive methods.

Original languageEnglish
Pages (from-to)1106-1110
Number of pages5
JournalNeuroReport
Volume21
Issue number17
DOIs
Publication statusPublished - 2010 Dec 8

Keywords

  • blood flow
  • human
  • magnetoencephalography
  • median nerve
  • neurovascular coupling
  • single trial
  • somatosensory cortex

ASJC Scopus subject areas

  • Neuroscience(all)

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    Kikuchi, M., Shitamichi, K., Ueno, S., Yoshimura, Y., Remijn, G. B., Nagao, K., Munesue, T., Iiyama, K., Tsubokawa, T., Haruta, Y., Inoue, Y., Watanabe, K., Hashimoto, T., Higashida, H., & Minabe, Y. (2010). Neurovascular coupling in the human somatosensory cortex: A single trial study. NeuroReport, 21(17), 1106-1110. https://doi.org/10.1097/WNR.0b013e3283406615