Neutrophil activation, antioxidant supplements and exercise-induced oxidative stress

Jonathan Peake, Katsuhiko Suzuki

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Neutrophils produce free radicals known as reactive oxygen species (ROS), which assist in the clearance of damaged host tissue. Tissue damage may occur during exercise due to muscle damage, thermal stress and ischaemia/reperfusion. When produced in excess, neutrophil-derived ROS may overwhelm the body's endogenous antioxidant defence mechanisms, and this can lead to oxidative stress. There is increasing evidence for links between oxidative stress and a variety of pathological disorders such as cardiovascular diseases, cancer, chronic inflammatory diseases and post-ischaemic organ injury. A small number of studies have investigated whether there is a link between neutrophil activation and oxidative stress during exercise. In this review, we have summarised the findings of these studies. Exercise promotes the release of neutrophils into the circulation, and some evidence suggests that neutrophils mobilised after exercise have an enhanced capacity to generate some forms of ROS when stimulated in vitro. Neutrophil activation during exercise may challenge endogenous antioxidant defence mechanisms, but does not appear to increase lipid markers of oxidative stress to any significant degree, at least in the circulation. Antioxidant supplements such as N-acetylcysteine are effective at attenuating increases in the capacity of neutrophils to generate ROS when stimulated in vitro, whereas vitamin E reduces tissue infiltration of neutrophils during exercise. Free radicals generated during intense exercise may lead to DNA damage in leukocytes, but it is unknown if this damage is the result of neutrophil activation. Exercise enhances the expression of inducible haem (heme)-oxygenase (HO-1) in neutrophils after exercise, however, it is uncertain whether oxidative stress is the stimulus for this response.

Original languageEnglish
Pages (from-to)129-141
Number of pages13
JournalExercise Immunology Review
Volume10
Publication statusPublished - 2004

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Neutrophil Activation
Oxidative Stress
Neutrophils
Antioxidants
Reactive Oxygen Species
Free Radicals
Heme Oxygenase (Decyclizing)
Heme Oxygenase-1
Neutrophil Infiltration
Acetylcysteine
Vitamin E
DNA Damage
Reperfusion
Leukocytes
Chronic Disease
Cardiovascular Diseases
Ischemia
Hot Temperature
Lipids
Muscles

Keywords

  • Antioxidant supplements
  • Free radical scavengers
  • N-acetylcysteine
  • Vitamin C
  • Vitamin E

ASJC Scopus subject areas

  • Immunology

Cite this

Neutrophil activation, antioxidant supplements and exercise-induced oxidative stress. / Peake, Jonathan; Suzuki, Katsuhiko.

In: Exercise Immunology Review, Vol. 10, 2004, p. 129-141.

Research output: Contribution to journalArticle

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