New aureothin derivative, alloaureothin, from Streptomyces sp. MM23

Jun Ya Ueda; Junko Hashimoto; Aya Nagai; Takuji Nakashima; Hisayuki Komaki; Kozue Anzai; Shigeaki Harayama; Takayuki Doi; Takashi Takahashi; Kazuo Nagasawa; Tohru Natsume; Motoki Takagi; Kazuo Shin-ya

doi:10.1038/ja.2007.41

New aureothin derivative, alloaureothin, from Streptomyces sp. MM23

Jun Ya Ueda, Junko Hashimoto, Aya Nagai, Takuji Nakashima, Hisayuki Komaki, Kozue Anzai, Shigeaki Harayama, Takayuki Doi, Takashi Takahashi, Kazuo Nagasawa, Tohru Natsume, Motoki Takagi^*, Kazuo Shin-ya

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A new polypropionate alloaureothin (1) possessing a nitro group, together with a known polypropionate aureothin (2), was isolated from mycelium of Streptomyces sp. MM23. The structure was determined on the basis of spectroscopic data. 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC₅₀ value of 30 μM.

Original language	English
Pages (from-to)	321-324
Number of pages	4
Journal	Journal of Antibiotics
Volume	60
Issue number	5
DOIs	https://doi.org/10.1038/ja.2007.41
Publication status	Published - 2007 May
Externally published	Yes

Keywords

Alloaureothin
Cytotoxic
Polypropionate
Streptomyces sp.

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1038/ja.2007.41

Cite this

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title = "New aureothin derivative, alloaureothin, from Streptomyces sp. MM23",

abstract = "A new polypropionate alloaureothin (1) possessing a nitro group, together with a known polypropionate aureothin (2), was isolated from mycelium of Streptomyces sp. MM23. The structure was determined on the basis of spectroscopic data. 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC50 value of 30 μM.",

keywords = "Alloaureothin, Cytotoxic, Polypropionate, Streptomyces sp.",

author = "Ueda, {Jun Ya} and Junko Hashimoto and Aya Nagai and Takuji Nakashima and Hisayuki Komaki and Kozue Anzai and Shigeaki Harayama and Takayuki Doi and Takashi Takahashi and Kazuo Nagasawa and Tohru Natsume and Motoki Takagi and Kazuo Shin-ya",

note = "Funding Information: Acknowledgement This work was supported by the grant from the New Energy and Industrial Technology Development Organization (NEDO) of Japan.",

year = "2007",

month = may,

doi = "10.1038/ja.2007.41",

language = "English",

volume = "60",

pages = "321--324",

journal = "Journal of Antibiotics",

issn = "0021-8820",

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TY - JOUR

T1 - New aureothin derivative, alloaureothin, from Streptomyces sp. MM23

AU - Ueda, Jun Ya

AU - Hashimoto, Junko

AU - Nagai, Aya

AU - Nakashima, Takuji

AU - Komaki, Hisayuki

AU - Anzai, Kozue

AU - Harayama, Shigeaki

AU - Doi, Takayuki

AU - Takahashi, Takashi

AU - Nagasawa, Kazuo

AU - Natsume, Tohru

AU - Takagi, Motoki

AU - Shin-ya, Kazuo

N1 - Funding Information: Acknowledgement This work was supported by the grant from the New Energy and Industrial Technology Development Organization (NEDO) of Japan.

PY - 2007/5

Y1 - 2007/5

N2 - A new polypropionate alloaureothin (1) possessing a nitro group, together with a known polypropionate aureothin (2), was isolated from mycelium of Streptomyces sp. MM23. The structure was determined on the basis of spectroscopic data. 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC50 value of 30 μM.

AB - A new polypropionate alloaureothin (1) possessing a nitro group, together with a known polypropionate aureothin (2), was isolated from mycelium of Streptomyces sp. MM23. The structure was determined on the basis of spectroscopic data. 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC50 value of 30 μM.

KW - Alloaureothin

KW - Cytotoxic

KW - Polypropionate

KW - Streptomyces sp.

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DO - 10.1038/ja.2007.41

M3 - Article

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SN - 0021-8820

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JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 5

ER -

New aureothin derivative, alloaureothin, from Streptomyces sp. MM23

Abstract

Keywords

ASJC Scopus subject areas

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