New challenge for studying flow-induced blood damage: Macroscale modeling and microscale verification

T. Yagi, S. Wakasa, N. Tokunaga, Y. Akimoto, T. Akutsu, K. Iwasaki, M. Umezu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Prosthetic heart valves often induce blood cell trauma, but its mechanism is not clearly understood due to the complexity of dynamical flows. We herein propose a new challenge, termed macroscale modeling and microscale verification. This report is the former, and here we aim to clarify the physical interpretation of Reynolds stress for flowing cells. One polymer and two mechanical valves are compared, and the Reynolds stress is visualized using a novel analytical technique including time-resolved particle image velocimetry and continuous wavelet transform. The method enables to analyze the dynamics of Reynolds stress in a spatial and temporal domain. As a result, it is found that the Reynolds stress should be considered as an indicator of impinging flows for circulating cells. Such flows may impulsively apply a colliding force on a membrane of flowing cells. As microscale verification based on this new hypothesis, we are currently investigating such collision phenomena of flowing cells using high-speed microfluidic techniques.

Original languageEnglish
Title of host publication13th International Conference on Biomedical Engineering - ICBME 2008
Pages1430-1433
Number of pages4
DOIs
Publication statusPublished - 2009 Dec 1
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: 2008 Dec 32008 Dec 6

Publication series

NameIFMBE Proceedings
Volume23
ISSN (Print)1680-0737

Conference

Conference13th International Conference on Biomedical Engineering, ICBME 2008
CountrySingapore
Period08/12/308/12/6

Keywords

  • collision
  • heart valve
  • hemolysis
  • impinging flow
  • turbulence

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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  • Cite this

    Yagi, T., Wakasa, S., Tokunaga, N., Akimoto, Y., Akutsu, T., Iwasaki, K., & Umezu, M. (2009). New challenge for studying flow-induced blood damage: Macroscale modeling and microscale verification. In 13th International Conference on Biomedical Engineering - ICBME 2008 (pp. 1430-1433). (IFMBE Proceedings; Vol. 23). https://doi.org/10.1007/978-3-540-92841-6_353