New challenge for studying flow-induced blood damage

Macroscale modeling and microscale verification

Takanobu Yagi, S. Wakasa, N. Tokunaga, Y. Akimoto, T. Akutsu, Kiyotaka Iwasaki, Mitsuo Umezu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Prosthetic heart valves often induce blood cell trauma, but its mechanism is not clearly understood due to the complexity of dynamical flows. We herein propose a new challenge, termed macroscale modeling and microscale verification. This report is the former, and here we aim to clarify the physical interpretation of Reynolds stress for flowing cells. One polymer and two mechanical valves are compared, and the Reynolds stress is visualized using a novel analytical technique including time-resolved particle image velocimetry and continuous wavelet transform. The method enables to analyze the dynamics of Reynolds stress in a spatial and temporal domain. As a result, it is found that the Reynolds stress should be considered as an indicator of impinging flows for circulating cells. Such flows may impulsively apply a colliding force on a membrane of flowing cells. As microscale verification based on this new hypothesis, we are currently investigating such collision phenomena of flowing cells using high-speed microfluidic techniques.

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages1430-1433
Number of pages4
Volume23
DOIs
Publication statusPublished - 2009
Event13th International Conference on Biomedical Engineering, ICBME 2008 -
Duration: 2008 Dec 32008 Dec 6

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
Period08/12/308/12/6

Fingerprint

Blood
Heart valve prostheses
Microfluidics
Velocity measurement
Wavelet transforms
Polymers
Cells
Membranes

Keywords

  • collision
  • heart valve
  • hemolysis
  • impinging flow
  • turbulence

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

New challenge for studying flow-induced blood damage : Macroscale modeling and microscale verification. / Yagi, Takanobu; Wakasa, S.; Tokunaga, N.; Akimoto, Y.; Akutsu, T.; Iwasaki, Kiyotaka; Umezu, Mitsuo.

IFMBE Proceedings. Vol. 23 2009. p. 1430-1433.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yagi, T, Wakasa, S, Tokunaga, N, Akimoto, Y, Akutsu, T, Iwasaki, K & Umezu, M 2009, New challenge for studying flow-induced blood damage: Macroscale modeling and microscale verification. in IFMBE Proceedings. vol. 23, pp. 1430-1433, 13th International Conference on Biomedical Engineering, ICBME 2008, 08/12/3. https://doi.org/10.1007/978-3-540-92841-6_353
Yagi, Takanobu ; Wakasa, S. ; Tokunaga, N. ; Akimoto, Y. ; Akutsu, T. ; Iwasaki, Kiyotaka ; Umezu, Mitsuo. / New challenge for studying flow-induced blood damage : Macroscale modeling and microscale verification. IFMBE Proceedings. Vol. 23 2009. pp. 1430-1433
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