TY - JOUR
T1 - New compounds, nanaomycin F and G, discovered by physicochemical screening from a culture broth of Streptomyces rosa subsp. notoensis OS-3966
AU - Nakashima, Takuji
AU - Boonsnongcheep, Panitch
AU - Kimura, Toru
AU - Iwatsuki, Masato
AU - Sato, Noriko
AU - Nonaka, Kenichi
AU - Prathanturarug, Sompop
AU - Takahashi, Yoko
AU - Omura, Satoshi
N1 - Funding Information:
This study was supported by funds from the Institute for Fermentation , Osaka (IFO), Japan. We thank Kenichiro Nagai, School of Pharmacy, Kitasato University, for measurement of MS spectra.
Publisher Copyright:
© 2015 The Society for Biotechnology, Japan.
PY - 2015/11
Y1 - 2015/11
N2 - Two new compounds, nanaomycin F and G, were isolated by physicochemical screening method from cultured broth of Streptomyces rosa subsp. notoensis OS-3966, which is known to produce nanaomycin A, B, C, D, and E. Nanaomycin F is a new nanaomycin analog, a 4a-hydroxyl analog of nanaomycin B. Nanaomycin G has a unique skeleton with 1-indanone infused with a tetrahydropyran ring. Nanaomycin A possesses broad antimicrobial activity but nanaomycin F and G demonstrated no bioactivity against all bacteria and fungi tested in this study. In addition, in both nanaomycin F and G, the production of superoxide radicals was majorly decreased in comparison to nanaomycin A. It was considered that the antimicrobial properties were lost as a result of the decrease in production of the superoxide radicals.
AB - Two new compounds, nanaomycin F and G, were isolated by physicochemical screening method from cultured broth of Streptomyces rosa subsp. notoensis OS-3966, which is known to produce nanaomycin A, B, C, D, and E. Nanaomycin F is a new nanaomycin analog, a 4a-hydroxyl analog of nanaomycin B. Nanaomycin G has a unique skeleton with 1-indanone infused with a tetrahydropyran ring. Nanaomycin A possesses broad antimicrobial activity but nanaomycin F and G demonstrated no bioactivity against all bacteria and fungi tested in this study. In addition, in both nanaomycin F and G, the production of superoxide radicals was majorly decreased in comparison to nanaomycin A. It was considered that the antimicrobial properties were lost as a result of the decrease in production of the superoxide radicals.
KW - Nanaomycin analogs
KW - Nanaomycin F
KW - Nanaomycin G
KW - Physicochemical screening
KW - Streptomyces sp.
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U2 - 10.1016/j.jbiosc.2015.03.018
DO - 10.1016/j.jbiosc.2015.03.018
M3 - Article
C2 - 26100318
AN - SCOPUS:84943352884
SN - 1389-1723
VL - 120
SP - 596
EP - 600
JO - Journal of Bioscience and Bioengineering
JF - Journal of Bioscience and Bioengineering
IS - 5
ER -