New compounds, nanaomycin F and G, discovered by physicochemical screening from a culture broth of Streptomyces rosa subsp. notoensis OS-3966

Takuji Nakashima, Panitch Boonsnongcheep, Toru Kimura, Masato Iwatsuki, Noriko Sato, Kenichi Nonaka, Sompop Prathanturarug, Yoko Takahashi, Satoshi Omura

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Two new compounds, nanaomycin F and G, were isolated by physicochemical screening method from cultured broth of Streptomyces rosa subsp. notoensis OS-3966, which is known to produce nanaomycin A, B, C, D, and E. Nanaomycin F is a new nanaomycin analog, a 4a-hydroxyl analog of nanaomycin B. Nanaomycin G has a unique skeleton with 1-indanone infused with a tetrahydropyran ring. Nanaomycin A possesses broad antimicrobial activity but nanaomycin F and G demonstrated no bioactivity against all bacteria and fungi tested in this study. In addition, in both nanaomycin F and G, the production of superoxide radicals was majorly decreased in comparison to nanaomycin A. It was considered that the antimicrobial properties were lost as a result of the decrease in production of the superoxide radicals.

Original languageEnglish
Pages (from-to)596-600
Number of pages5
JournalJournal of Bioscience and Bioengineering
Volume120
Issue number5
DOIs
Publication statusPublished - 2015 Nov
Externally publishedYes

Keywords

  • Nanaomycin analogs
  • Nanaomycin F
  • Nanaomycin G
  • Physicochemical screening
  • Streptomyces sp.

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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