New implications of memory mechanisms for Alzheimer's disease.

R. Etcheberrigaray, Etsuro Ito, K. Oka, B. Tofel-Grehl, G. E. Gibson, D. L. Alkon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Previous studies of molluscan and mammalian neural networks have implicated potassium channels, calcium-dependent kinases and a small G-protein (Cp20) in associative memory storage. Since Alzheimer's disease is characterized by memory deficits and possible changes in PKC activation, we studied potassium channel function in AD. Patch-clamp experiments revealed the absence of a 113 pS TEA-sensitive K+ channel in fibroblasts from Alzheimer's but not control patients. These results suggest a role for potassium channel dysfunction in Alzheimer's disease.

Original languageEnglish
JournalNeuroscience Research Communications
Volume12
Issue numberSUPPL. 1
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Potassium Channels
Alzheimer Disease
Calcium-Activated Potassium Channels
Monomeric GTP-Binding Proteins
Memory Disorders
Phosphotransferases
Fibroblasts
deferiprone

Keywords

  • Alzheimer's disease
  • Memory
  • Potassium channels

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Etcheberrigaray, R., Ito, E., Oka, K., Tofel-Grehl, B., Gibson, G. E., & Alkon, D. L. (1993). New implications of memory mechanisms for Alzheimer's disease. Neuroscience Research Communications, 12(SUPPL. 1).

New implications of memory mechanisms for Alzheimer's disease. / Etcheberrigaray, R.; Ito, Etsuro; Oka, K.; Tofel-Grehl, B.; Gibson, G. E.; Alkon, D. L.

In: Neuroscience Research Communications, Vol. 12, No. SUPPL. 1, 1993.

Research output: Contribution to journalArticle

Etcheberrigaray, R, Ito, E, Oka, K, Tofel-Grehl, B, Gibson, GE & Alkon, DL 1993, 'New implications of memory mechanisms for Alzheimer's disease.', Neuroscience Research Communications, vol. 12, no. SUPPL. 1.
Etcheberrigaray R, Ito E, Oka K, Tofel-Grehl B, Gibson GE, Alkon DL. New implications of memory mechanisms for Alzheimer's disease. Neuroscience Research Communications. 1993;12(SUPPL. 1).
Etcheberrigaray, R. ; Ito, Etsuro ; Oka, K. ; Tofel-Grehl, B. ; Gibson, G. E. ; Alkon, D. L. / New implications of memory mechanisms for Alzheimer's disease. In: Neuroscience Research Communications. 1993 ; Vol. 12, No. SUPPL. 1.
@article{80ad43cc4b67408aaf02b64320d6ae35,
title = "New implications of memory mechanisms for Alzheimer's disease.",
abstract = "Previous studies of molluscan and mammalian neural networks have implicated potassium channels, calcium-dependent kinases and a small G-protein (Cp20) in associative memory storage. Since Alzheimer's disease is characterized by memory deficits and possible changes in PKC activation, we studied potassium channel function in AD. Patch-clamp experiments revealed the absence of a 113 pS TEA-sensitive K+ channel in fibroblasts from Alzheimer's but not control patients. These results suggest a role for potassium channel dysfunction in Alzheimer's disease.",
keywords = "Alzheimer's disease, Memory, Potassium channels",
author = "R. Etcheberrigaray and Etsuro Ito and K. Oka and B. Tofel-Grehl and Gibson, {G. E.} and Alkon, {D. L.}",
year = "1993",
language = "English",
volume = "12",
journal = "Neuroscience Research Communications",
issn = "0893-6609",
publisher = "John Wiley and Sons Inc.",
number = "SUPPL. 1",

}

TY - JOUR

T1 - New implications of memory mechanisms for Alzheimer's disease.

AU - Etcheberrigaray, R.

AU - Ito, Etsuro

AU - Oka, K.

AU - Tofel-Grehl, B.

AU - Gibson, G. E.

AU - Alkon, D. L.

PY - 1993

Y1 - 1993

N2 - Previous studies of molluscan and mammalian neural networks have implicated potassium channels, calcium-dependent kinases and a small G-protein (Cp20) in associative memory storage. Since Alzheimer's disease is characterized by memory deficits and possible changes in PKC activation, we studied potassium channel function in AD. Patch-clamp experiments revealed the absence of a 113 pS TEA-sensitive K+ channel in fibroblasts from Alzheimer's but not control patients. These results suggest a role for potassium channel dysfunction in Alzheimer's disease.

AB - Previous studies of molluscan and mammalian neural networks have implicated potassium channels, calcium-dependent kinases and a small G-protein (Cp20) in associative memory storage. Since Alzheimer's disease is characterized by memory deficits and possible changes in PKC activation, we studied potassium channel function in AD. Patch-clamp experiments revealed the absence of a 113 pS TEA-sensitive K+ channel in fibroblasts from Alzheimer's but not control patients. These results suggest a role for potassium channel dysfunction in Alzheimer's disease.

KW - Alzheimer's disease

KW - Memory

KW - Potassium channels

UR - http://www.scopus.com/inward/record.url?scp=0027203249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027203249&partnerID=8YFLogxK

M3 - Article

VL - 12

JO - Neuroscience Research Communications

JF - Neuroscience Research Communications

SN - 0893-6609

IS - SUPPL. 1

ER -