New implications of memory mechanisms for Alzheimer's disease.

R. Etcheberrigaray, E. Ito, K. Oka, B. Tofel-Grehl, G. E. Gibson, D. L. Alkon

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Abstract

Previous studies of molluscan and mammalian neural networks have implicated potassium channels, calcium-dependent kinases and a small G-protein (Cp20) in associative memory storage. Since Alzheimer's disease is characterized by memory deficits and possible changes in PKC activation, we studied potassium channel function in AD. Patch-clamp experiments revealed the absence of a 113 pS TEA-sensitive K+ channel in fibroblasts from Alzheimer's but not control patients. These results suggest a role for potassium channel dysfunction in Alzheimer's disease.

Original languageEnglish
Pages (from-to)S7-S10
JournalNeuroscience Research Communications
Volume12
Issue numberSUPPL. 1
Publication statusPublished - 1993 Aug 27

Keywords

  • Alzheimer's disease
  • Memory
  • Potassium channels

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Etcheberrigaray, R., Ito, E., Oka, K., Tofel-Grehl, B., Gibson, G. E., & Alkon, D. L. (1993). New implications of memory mechanisms for Alzheimer's disease. Neuroscience Research Communications, 12(SUPPL. 1), S7-S10.