New insights into additive structure effect on crystal agglomeration of L-valine

H. Yoshiura, H. Nagano, Izumi Hirasawa

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Specific small amounts of amino acids caused agglomeration of L-valine (L-Val) crystals during evaporative crystallization from aqueous solutions. The agglomeration of L-Val occurred only under acidic condition when guest amino acids satisfied several conditions. Only L-form amino acids that have carboxylic acid groups and sufficiently long alkyl chain in the side-chains could induce agglomeration of L-Val. The length of alkyl chain in the side-chains controls the degree of agglomeration. Data indicated only 0.5wt% of L-2-aminoadipic acid, which has a similar chemical structure to L-glutamic acid (L-Glu), produced the large agglomerates >1000μm. The particle size was ∼500μm when using the same amount of L-Glu. Based on the results from previous tests and this paper, the whole mechanism for the L-Val agglomeration in the presence of specific guest amino acids has been revealed.

    Original languageEnglish
    Pages (from-to)2023-2028
    Number of pages6
    JournalChemical Engineering and Technology
    Volume36
    Issue number12
    DOIs
    Publication statusPublished - 2013 Dec

    Fingerprint

    Valine
    Agglomeration
    Amino acids
    Crystals
    Amino Acids
    2-Aminoadipic Acid
    Acids
    Carboxylic Acids
    Crystallization
    Carboxylic acids
    Glutamic Acid
    Particle size

    Keywords

    • Agglomeration
    • Amino acids
    • Crystallization
    • Impurities

    ASJC Scopus subject areas

    • Chemical Engineering(all)
    • Chemistry(all)
    • Industrial and Manufacturing Engineering

    Cite this

    New insights into additive structure effect on crystal agglomeration of L-valine. / Yoshiura, H.; Nagano, H.; Hirasawa, Izumi.

    In: Chemical Engineering and Technology, Vol. 36, No. 12, 12.2013, p. 2023-2028.

    Research output: Contribution to journalArticle

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