New type of biodegradable porous scaffolds for tissue-engineered articular cartilage

Makoto Kawanishi, Takashi Ushida, Tadashi Kaneko, Hideo Niwa, Toru Fukubayashi, Kozo Nakamura, Hiromi Oda, Sakae Tanaka, Tetsuya Tateishi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Three-dimensional biodegradable porous scaffolds play an important role in tissue engineering. We created double-layered porous scaffolds composed of synthetic biodegradable polymers by combining freeze-drying and porogen leaching techniques to create tissue- engineered articular cartilage. The pore structures had two layers, a leaching side (upper) and a freeze-drying side (lower). The latter had columnar pores to simulate a radial zone, while the leaching side simulated the tangential zone of the articular cartilage. In this study, we showed that this structure enabled the uniform seeding of goat chondrocytes in the scaffolds, and with low rates of leakage.

Original languageEnglish
Pages (from-to)431-435
Number of pages5
JournalMaterials Science and Engineering C
Volume24
Issue number3
DOIs
Publication statusPublished - 2004 Apr 1
Externally publishedYes

Keywords

  • Articular cartilage
  • Biodegradable polymer
  • Tissue engineering

ASJC Scopus subject areas

  • Biomaterials

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  • Cite this

    Kawanishi, M., Ushida, T., Kaneko, T., Niwa, H., Fukubayashi, T., Nakamura, K., Oda, H., Tanaka, S., & Tateishi, T. (2004). New type of biodegradable porous scaffolds for tissue-engineered articular cartilage. Materials Science and Engineering C, 24(3), 431-435. https://doi.org/10.1016/j.msec.2003.11.008