Newly identified repeat sequences, derived from human chromosome 21qter, are also localized in the subtelomeric region of particular chromosomes and 2q13, and are conserved in the chimpanzee genome

H. S. Park, M. Nogami, K. Okumura, Masahira Hattori, Y. Sakaki, A. Fujiyama

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Subtelomeric regions have been a target of structural and functional studies of human chromosomes. Markers having a defined structure are especially useful to such studies. Here, we report 93 bp tandem repeat sequences found in the subtelomeric region of human chromosome 21q. They were also detected in the telomeric region of several other chromosomes. Interestingly, the repeat was also found in the 2q13 region which is known to be a position of chromosomal fusion, a major difference between the human and chimpanzee karyotypes. To the best of our knowledge, this repetitive sequence is a new member of human subtelomeric interspersed repeats. (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)167-169
Number of pages3
JournalFEBS Letters
Volume475
Issue number3
DOIs
Publication statusPublished - 2000 Jun 23
Externally publishedYes

Keywords

  • Human chromosome
  • Primate
  • Repeat sequence
  • Subtelomeric interspersed repeat
  • Telomere

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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