Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

Eva Koch; Ryosuke Takise; Armido Studer; Junichiro Yamaguchi; Kenichiro Itami

doi:10.1039/c4cc08426h

Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

Eva Koch, Ryosuke Takise, Armido Studer, Junichiro Yamaguchi^*, Kenichiro Itami

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

A nickel-catalyzed α-arylation of esters and amides with phenol derivatives has been accomplished. In the presence of our unique nickel catalyst, prepared in situ from Ni(cod)₂, 3,4-bis(dicyclohexylphosphino)thiophene (dcypt), and K₃PO₄, various esters and amides undergo α-arylation with O-arylpivalates or O-arylcarbamates to afford the corresponding coupling products. The thus obtained α-aryl esters and amides are useful precursors of privileged motifs such as α-arylcarboxylic acids and β-arylamines. This journal is

Original language	English
Pages (from-to)	855-857
Number of pages	3
Journal	Chemical Communications
Volume	51
Issue number	5
DOIs	https://doi.org/10.1039/c4cc08426h
Publication status	Published - 2015 Jan 18
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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T1 - Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

AU - Koch, Eva

AU - Takise, Ryosuke

AU - Studer, Armido

AU - Yamaguchi, Junichiro

AU - Itami, Kenichiro

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2015/1/18

Y1 - 2015/1/18

N2 - A nickel-catalyzed α-arylation of esters and amides with phenol derivatives has been accomplished. In the presence of our unique nickel catalyst, prepared in situ from Ni(cod)2, 3,4-bis(dicyclohexylphosphino)thiophene (dcypt), and K3PO4, various esters and amides undergo α-arylation with O-arylpivalates or O-arylcarbamates to afford the corresponding coupling products. The thus obtained α-aryl esters and amides are useful precursors of privileged motifs such as α-arylcarboxylic acids and β-arylamines. This journal is

AB - A nickel-catalyzed α-arylation of esters and amides with phenol derivatives has been accomplished. In the presence of our unique nickel catalyst, prepared in situ from Ni(cod)2, 3,4-bis(dicyclohexylphosphino)thiophene (dcypt), and K3PO4, various esters and amides undergo α-arylation with O-arylpivalates or O-arylcarbamates to afford the corresponding coupling products. The thus obtained α-aryl esters and amides are useful precursors of privileged motifs such as α-arylcarboxylic acids and β-arylamines. This journal is

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Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

Abstract

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