Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

Eva Koch, Ryosuke Takise, Armido Studer, Junichiro Yamaguchi, Kenichiro Itami

Research output: Contribution to journalArticle

60 Citations (Scopus)


A nickel-catalyzed α-arylation of esters and amides with phenol derivatives has been accomplished. In the presence of our unique nickel catalyst, prepared in situ from Ni(cod)2, 3,4-bis(dicyclohexylphosphino)thiophene (dcypt), and K3PO4, various esters and amides undergo α-arylation with O-arylpivalates or O-arylcarbamates to afford the corresponding coupling products. The thus obtained α-aryl esters and amides are useful precursors of privileged motifs such as α-arylcarboxylic acids and β-arylamines. This journal is

Original languageEnglish
Pages (from-to)855-857
Number of pages3
JournalChemical Communications
Issue number5
Publication statusPublished - 2015 Jan 18
Externally publishedYes


ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Medicine(all)

Cite this