Nickel-catalyzed alkenylation and alkylation of fluoroarenes via activation of C-H bond over C-F bond

Yoshiaki Nakao, Natsuko Kashihara, Stephen Kyalo Kanyiva, Tamejiro Hiyama

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

Nickel/P(c-C5H9)3 (PCyp3) catalyst effects the addition reactions of fluoroarenes across alkynes, 1,3-dienes, and vinylarenes via the activation of C-H bonds over C-F bonds. The acidic C-H bonds located ortho to fluorine are exclusively activated to afford a range of alkenylated and alkylated fluoroarenes.

Original languageEnglish
Pages (from-to)16170-16171
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number48
DOIs
Publication statusPublished - 2008 Dec 3
Externally publishedYes

Fingerprint

Alkenylation
Addition reactions
Alkynes
Fluorine
Alkylation
Nickel
Chemical activation
Catalysts

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Nickel-catalyzed alkenylation and alkylation of fluoroarenes via activation of C-H bond over C-F bond. / Nakao, Yoshiaki; Kashihara, Natsuko; Kanyiva, Stephen Kyalo; Hiyama, Tamejiro.

In: Journal of the American Chemical Society, Vol. 130, No. 48, 03.12.2008, p. 16170-16171.

Research output: Contribution to journalArticle

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