Nickel-Catalyzed Aromatic C–H Functionalization

Junichiro Yamaguchi, Kei Muto, Kenichiro Itami

    Research output: Contribution to journalReview article

    36 Citations (Scopus)


    Catalytic C–H functionalization using transition metals has received significant interest from organic chemists because it provides a new strategy to construct carbon–carbon bonds and carbon–heteroatom bonds in highly functionalized, complex molecules without pre-functionalization. Recently, inexpensive catalysts based on transition metals such as copper, iron, cobalt, and nickel have seen more use in the laboratory. This review describes recent progress in nickel-catalyzed aromatic C–H functionalization reactions classified by reaction types and reaction partners. Furthermore, some reaction mechanisms are described and cutting-edge syntheses of natural products and pharmaceuticals using nickel-catalyzed aromatic C–H functionalization are presented.

    Original languageEnglish
    Article number55
    JournalTopics in Current Chemistry
    Issue number4
    Publication statusPublished - 2016 Aug 1



    • Arenes
    • Catalyst
    • C–H activation
    • C–H functionalization
    • Heteroarenes
    • Nickel

    ASJC Scopus subject areas

    • Chemistry(all)

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