Nickel-Catalyzed Aromatic C–H Functionalization

Junichiro Yamaguchi*, Kei Muto, Kenichiro Itami

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

63 Citations (Scopus)


Catalytic C–H functionalization using transition metals has received significant interest from organic chemists because it provides a new strategy to construct carbon–carbon bonds and carbon–heteroatom bonds in highly functionalized, complex molecules without pre-functionalization. Recently, inexpensive catalysts based on transition metals such as copper, iron, cobalt, and nickel have seen more use in the laboratory. This review describes recent progress in nickel-catalyzed aromatic C–H functionalization reactions classified by reaction types and reaction partners. Furthermore, some reaction mechanisms are described and cutting-edge syntheses of natural products and pharmaceuticals using nickel-catalyzed aromatic C–H functionalization are presented.

Original languageEnglish
Article number55
JournalTopics in Current Chemistry
Issue number4
Publication statusPublished - 2016 Aug 1


  • Arenes
  • Catalyst
  • C–H activation
  • C–H functionalization
  • Heteroarenes
  • Nickel

ASJC Scopus subject areas

  • Chemistry(all)


Dive into the research topics of 'Nickel-Catalyzed Aromatic C–H Functionalization'. Together they form a unique fingerprint.

Cite this