Nickel-Catalyzed Aromatic C–H Functionalization

Junichiro Yamaguchi, Kei Muto, Kenichiro Itami

    Research output: Contribution to journalReview article

    35 Citations (Scopus)

    Abstract

    Catalytic C–H functionalization using transition metals has received significant interest from organic chemists because it provides a new strategy to construct carbon–carbon bonds and carbon–heteroatom bonds in highly functionalized, complex molecules without pre-functionalization. Recently, inexpensive catalysts based on transition metals such as copper, iron, cobalt, and nickel have seen more use in the laboratory. This review describes recent progress in nickel-catalyzed aromatic C–H functionalization reactions classified by reaction types and reaction partners. Furthermore, some reaction mechanisms are described and cutting-edge syntheses of natural products and pharmaceuticals using nickel-catalyzed aromatic C–H functionalization are presented.

    Original languageEnglish
    Article number55
    JournalTopics in Current Chemistry
    Volume374
    Issue number4
    DOIs
    Publication statusPublished - 2016 Aug 1

    Fingerprint

    Nickel
    Transition metals
    Cobalt
    Biological Products
    Copper
    Iron
    Catalysts
    Molecules
    Pharmaceutical Preparations

    Keywords

    • Arenes
    • Catalyst
    • C–H activation
    • C–H functionalization
    • Heteroarenes
    • Nickel

    ASJC Scopus subject areas

    • Chemistry(all)

    Cite this

    Nickel-Catalyzed Aromatic C–H Functionalization. / Yamaguchi, Junichiro; Muto, Kei; Itami, Kenichiro.

    In: Topics in Current Chemistry, Vol. 374, No. 4, 55, 01.08.2016.

    Research output: Contribution to journalReview article

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