Nickel-catalyzed biaryl coupling of heteroarenes and aryl halides/triflates

Jérôme Canivet, Junichiro Yamaguchi, Ikuya Ban, Kenichiro Itami

Research output: Contribution to journalArticle

249 Citations (Scopus)

Abstract

Ni-based catalytic systems for the arylation of heteroarenes with aryl halides and triflates have been established. Ni(OAc)2/bipy is a general catalyst for aryl bromides/iodides, and Ni(OAc)2/dppf is effective for aryl chlorides/triflates. Thiazole, benzothiazole, oxazole, benzoxazole, and benzimidazole are applicable as heteroarene coupling partners. A rapid synthesis of febuxostat, a drug for gout and hyperuricemia, is also demonstrated.

Original languageEnglish
Pages (from-to)1733-1736
Number of pages4
JournalOrganic Letters
Volume11
Issue number8
DOIs
Publication statusPublished - 2009 Apr 16

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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