Nickel-catalyzed C-H/C-O coupling of azoles with phenol derivatives

Kei Muto, Junichiro Yamaguchi, Kenichiro Itami*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

300 Citations (Scopus)


The first nickel-catalyzed C-H bond arylation of azoles with phenol derivatives is described. The new Ni(cod) 2/dcype catalytic system is active for the coupling of various phenol derivatives such as esters, carbamates, carbonates, sulfamates, triflates, tosylates, and mesylates. With this C-H/C-O biaryl coupling, we synthesized a series of privileged 2-arylazoles, including biologically active alkaloids. Moreover, we demonstrated the utility of the present reaction for functionalizing estrone and quinine.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalJournal of the American Chemical Society
Issue number1
Publication statusPublished - 2012 Jan 11
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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