Nitric oxide

Is it the cause of muscle soreness?

Zsolt Radak, Hisashi Naito, Albert W. Taylor, Sataro Goto

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Skeletal muscle hosts all of the isoforms of nitric oxide synthase (NOS). It is well documented that nitric oxide (NO) regulates force generation and satellite cell activation, and therefore, damage repair of skeletal muscle. NO can also activate nociceptors of C-fibers, thereby causing the sensation of pain. Although delayed-onset of muscle soreness (DOMS) is associated with decreased maximal force generation, pain sensation and sarcomere damage, there is a paucity of research linking NO and DOMS. The present mini-review attempts to elucidate the possible relationship between NO and DOMS, based upon current literature.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalNitric Oxide - Biology and Chemistry
Volume26
Issue number2
DOIs
Publication statusPublished - 2012 Feb 15
Externally publishedYes

Fingerprint

Myalgia
Muscle
Nitric Oxide
Skeletal Muscle
Pain
Unmyelinated Nerve Fibers
Sarcomeres
Nociceptors
Nitric Oxide Synthase
Protein Isoforms
Repair
Chemical activation
Satellites
Research
Fibers

Keywords

  • Exercise
  • Hormesis
  • Muscle damage
  • Pain
  • Skeletal muscle

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Cancer Research
  • Physiology

Cite this

Nitric oxide : Is it the cause of muscle soreness? / Radak, Zsolt; Naito, Hisashi; Taylor, Albert W.; Goto, Sataro.

In: Nitric Oxide - Biology and Chemistry, Vol. 26, No. 2, 15.02.2012, p. 89-94.

Research output: Contribution to journalReview article

Radak, Zsolt ; Naito, Hisashi ; Taylor, Albert W. ; Goto, Sataro. / Nitric oxide : Is it the cause of muscle soreness?. In: Nitric Oxide - Biology and Chemistry. 2012 ; Vol. 26, No. 2. pp. 89-94.
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