Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

Kentaro Takada; Youichi Nakao; Shigeki Matsunaga; Rob W M Van Soest; Nobuhiro Fusetani

doi:10.1021/np010480n

Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

Kentaro Takada, Youichi Nakao, Shigeki Matsunaga, Rob W M Van Soest, Nobuhiro Fusetani

Research output: Contribution to journal › Article

31 Citations (Scopus)

Abstract

A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC₅₀ value of 0.46μg/mL.

Original language	English
Pages (from-to)	411-413
Number of pages	3
Journal	Journal of Natural Products
Volume	65
Issue number	3
DOIs	https://doi.org/10.1021/np010480n
Publication status	Published - 2002
Externally published	Yes

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ASJC Scopus subject areas

Plant Science
Chemistry (miscellaneous)
Drug Discovery
Organic Chemistry
Pharmacology

Cite this

Takada, K., Nakao, Y., Matsunaga, S., Van Soest, R. W. M., & Fusetani, N. (2002). Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis. Journal of Natural Products, 65(3), 411-413. https://doi.org/10.1021/np010480n

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Access to Document

10.1021/np010480n