Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

Kentaro Takada; Yoichi Nakao; Shigeki Matsunaga; Rob W.M. Van Soest; Nobuhiro Fusetani

doi:10.1021/np010480n

Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

Kentaro Takada, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest, Nobuhiro Fusetani

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC₅₀ value of 0.46μg/mL.

Original language	English
Pages (from-to)	411-413
Number of pages	3
Journal	Journal of Natural Products
Volume	65
Issue number	3
DOIs	https://doi.org/10.1021/np010480n
Publication status	Published - 2002 Apr 9
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np010480n

Fingerprint Dive into the research topics of 'Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis'. Together they form a unique fingerprint.

Cite this

@article{e28de6eaa5784276b27a6a5af4ffe27f,

title = "Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis",

abstract = "A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.",

author = "Kentaro Takada and Yoichi Nakao and Shigeki Matsunaga and {Van Soest}, {Rob W.M.} and Nobuhiro Fusetani",

year = "2002",

month = apr,

day = "9",

doi = "10.1021/np010480n",

language = "English",

volume = "65",

pages = "411--413",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "3",

}

TY - JOUR

T1 - Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

AU - Takada, Kentaro

AU - Nakao, Yoichi

AU - Matsunaga, Shigeki

AU - Van Soest, Rob W.M.

AU - Fusetani, Nobuhiro

PY - 2002/4/9

Y1 - 2002/4/9

N2 - A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.

AB - A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.

UR - http://www.scopus.com/inward/record.url?scp=0036196283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036196283&partnerID=8YFLogxK

U2 - 10.1021/np010480n

DO - 10.1021/np010480n

M3 - Article

C2 - 11908993

AN - SCOPUS:0036196283

VL - 65

SP - 411

EP - 413

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 3

ER -

Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this