Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

Kentaro Takada; Yoichi Nakao; Shigeki Matsunaga; Rob W.M. Van Soest; Nobuhiro Fusetani

doi:10.1021/np010480n

Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

Kentaro Takada, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest, Nobuhiro Fusetani

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC₅₀ value of 0.46μg/mL.

Original language	English
Pages (from-to)	411-413
Number of pages	3
Journal	Journal of Natural Products
Volume	65
Issue number	3
DOIs	https://doi.org/10.1021/np010480n
Publication status	Published - 2002 Apr 9
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np010480n

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abstract = "A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.",

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AU - Fusetani, Nobuhiro

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