Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

Kentaro Takada, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest, Nobuhiro Fusetani

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.

Original languageEnglish
Pages (from-to)411-413
Number of pages3
JournalJournal of Natural Products
Volume65
Issue number3
DOIs
Publication statusPublished - 2002 Apr 9
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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