Abstract
A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.
| Original language | English |
|---|---|
| Pages (from-to) | 411-413 |
| Number of pages | 3 |
| Journal | Journal of Natural Products |
| Volume | 65 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Plant Science
- Chemistry (miscellaneous)
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis. / Takada, Kentaro; Nakao, Youichi; Matsunaga, Shigeki; Van Soest, Rob W M; Fusetani, Nobuhiro.
In: Journal of Natural Products, Vol. 65, No. 3, 2002, p. 411-413.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis
AU - Takada, Kentaro
AU - Nakao, Youichi
AU - Matsunaga, Shigeki
AU - Van Soest, Rob W M
AU - Fusetani, Nobuhiro
PY - 2002
Y1 - 2002
N2 - A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.
AB - A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.
UR - http://www.scopus.com/inward/record.url?scp=0036196283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036196283&partnerID=8YFLogxK
U2 - 10.1021/np010480n
DO - 10.1021/np010480n
M3 - Article
C2 - 11908993
AN - SCOPUS:0036196283
VL - 65
SP - 411
EP - 413
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 3
ER -