Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

Kentaro Takada, Youichi Nakao, Shigeki Matsunaga, Rob W M Van Soest, Nobuhiro Fusetani

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.

Original languageEnglish
Pages (from-to)411-413
Number of pages3
JournalJournal of Natural Products
Volume65
Issue number3
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

sialidase
Saponins
Neuraminidase
Porifera
saponins
trisaccharides
Trisaccharides
Clostridium
Clostridium perfringens
Inhibitory Concentration 50
inhibitory concentration 50
Bacteria
Nuclear magnetic resonance
bacteria
nobiloside
penasterol

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis. / Takada, Kentaro; Nakao, Youichi; Matsunaga, Shigeki; Van Soest, Rob W M; Fusetani, Nobuhiro.

In: Journal of Natural Products, Vol. 65, No. 3, 2002, p. 411-413.

Research output: Contribution to journalArticle

Takada, Kentaro ; Nakao, Youichi ; Matsunaga, Shigeki ; Van Soest, Rob W M ; Fusetani, Nobuhiro. / Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis. In: Journal of Natural Products. 2002 ; Vol. 65, No. 3. pp. 411-413.
@article{e28de6eaa5784276b27a6a5af4ffe27f,
title = "Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis",
abstract = "A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.",
author = "Kentaro Takada and Youichi Nakao and Shigeki Matsunaga and {Van Soest}, {Rob W M} and Nobuhiro Fusetani",
year = "2002",
doi = "10.1021/np010480n",
language = "English",
volume = "65",
pages = "411--413",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "3",

}

TY - JOUR

T1 - Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

AU - Takada, Kentaro

AU - Nakao, Youichi

AU - Matsunaga, Shigeki

AU - Van Soest, Rob W M

AU - Fusetani, Nobuhiro

PY - 2002

Y1 - 2002

N2 - A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.

AB - A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.

UR - http://www.scopus.com/inward/record.url?scp=0036196283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036196283&partnerID=8YFLogxK

U2 - 10.1021/np010480n

DO - 10.1021/np010480n

M3 - Article

C2 - 11908993

AN - SCOPUS:0036196283

VL - 65

SP - 411

EP - 413

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 3

ER -