Non-chelation controlled 1,3-asymmetric induction in β-chiral acylsilanes

Masahisa Nakada, Yasuharu Urano, Susumu Kobayashi, Masaji Ohno

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The diastereoselectivity of nucleophilic addition to β-chiral acylsilanes is examined, and our method is applied to the stereoselective synthesis of calcitriol lactone, a major metabolite of vitamine D3.

Original languageEnglish
Pages (from-to)741-744
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number5
DOIs
Publication statusPublished - 1994
Externally publishedYes

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Calcitriol
Lactones
Metabolites

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Non-chelation controlled 1,3-asymmetric induction in β-chiral acylsilanes. / Nakada, Masahisa; Urano, Yasuharu; Kobayashi, Susumu; Ohno, Masaji.

In: Tetrahedron Letters, Vol. 35, No. 5, 1994, p. 741-744.

Research output: Contribution to journalArticle

Nakada, Masahisa ; Urano, Yasuharu ; Kobayashi, Susumu ; Ohno, Masaji. / Non-chelation controlled 1,3-asymmetric induction in β-chiral acylsilanes. In: Tetrahedron Letters. 1994 ; Vol. 35, No. 5. pp. 741-744.
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