Non-chelation controlled 1,3-asymmetric induction in β-chiral acylsilanes

Masahisa Nakada, Yasuharu Urano, Susumu Kobayashi, Masaji Ohno

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The diastereoselectivity of nucleophilic addition to β-chiral acylsilanes is examined, and our method is applied to the stereoselective synthesis of calcitriol lactone, a major metabolite of vitamine D3.

Original languageEnglish
Pages (from-to)741-744
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number5
DOIs
Publication statusPublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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