Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system-

Hironori Suzaki, Naoki Kobayashi, Takashi Nagaoka, Kiyotaka Iwasaki, Mitsuo Umezu, Sunao Takeda, Tatsuo Togawa

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    16 Citations (Scopus)

    Abstract

    Total hemoglobin (tHb), carboxyhemoglobin (COHb), and methemoglobin (MetHb) are usually measured with a CO-oximeter. Noninvasive and continuous measurement of these blood components is expected to decrease the pain of a patient. Therefore, we developed an instrument to measure oxygen saturation (SpO 2), tHb, COHb, and MetHb non-invasively. Multiwavelength LED (600, 625, 660, 760, 800, 940, and 1300 nm) and a combined detector (Si, InGaAs) were built into the instrument (Seven wavelengths transparent pulse spectrophotometer). We used the Waseda mock circulatory system, which can simulate blood circulation in tissues and generate a pulse wave mechanically, to estimate the instrument's performance. Furthermore we proposed new calculation formula including DC components of optical density (this method). Under conditions without any change of other components, the mean error ± standard deviation between this method and the CO-oximetry were SaO 2=0.0±1.4%, tHb=0.0±0.0 g/dl, COHb=0.0±2.0%, and MetHb=0.0±0.3%. When the concentration of other components was changed, this method showed mean errors and standard deviations of SaO 2=0.2±1.6%, tHb=0.0±0.4 g/dl, COHb=0.5±4.1%, and MetHb=0.0±0.3%.

    Original languageEnglish
    Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
    Pages799-802
    Number of pages4
    DOIs
    Publication statusPublished - 2006
    Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY
    Duration: 2006 Aug 302006 Sep 3

    Other

    Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
    CityNew York, NY
    Period06/8/3006/9/3

    Fingerprint

    Carboxyhemoglobin
    Methemoglobin
    Hemoglobin
    Spectrophotometry
    Hemoglobins
    Derivatives
    Carbon Monoxide
    Oximeters
    Density (optical)
    Spectrophotometers
    Hemodynamics
    Light emitting diodes
    Blood
    Tissue
    Oxygen
    Detectors
    Wavelength

    ASJC Scopus subject areas

    • Bioengineering

    Cite this

    Suzaki, H., Kobayashi, N., Nagaoka, T., Iwasaki, K., Umezu, M., Takeda, S., & Togawa, T. (2006). Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system-. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 799-802). [4029808] https://doi.org/10.1109/IEMBS.2006.260273

    Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system-. / Suzaki, Hironori; Kobayashi, Naoki; Nagaoka, Takashi; Iwasaki, Kiyotaka; Umezu, Mitsuo; Takeda, Sunao; Togawa, Tatsuo.

    Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 799-802 4029808.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Suzaki, H, Kobayashi, N, Nagaoka, T, Iwasaki, K, Umezu, M, Takeda, S & Togawa, T 2006, Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system-. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4029808, pp. 799-802, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, 06/8/30. https://doi.org/10.1109/IEMBS.2006.260273
    Suzaki H, Kobayashi N, Nagaoka T, Iwasaki K, Umezu M, Takeda S et al. Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system-. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 799-802. 4029808 https://doi.org/10.1109/IEMBS.2006.260273
    Suzaki, Hironori ; Kobayashi, Naoki ; Nagaoka, Takashi ; Iwasaki, Kiyotaka ; Umezu, Mitsuo ; Takeda, Sunao ; Togawa, Tatsuo. / Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system-. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. pp. 799-802
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    AU - Nagaoka, Takashi

    AU - Iwasaki, Kiyotaka

    AU - Umezu, Mitsuo

    AU - Takeda, Sunao

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