Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system-

Hironori Suzaki, Naoki Kobayashi, Takashi Nagaoka, Kiyotaka Iwasaki, Mitsuo Umezu, Sunao Takeda, Tatsuo Togawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

17 Citations (Scopus)

Abstract

Total hemoglobin (tHb), carboxyhemoglobin (COHb), and methemoglobin (MetHb) are usually measured with a CO-oximeter. Noninvasive and continuous measurement of these blood components is expected to decrease the pain of a patient. Therefore, we developed an instrument to measure oxygen saturation (SpO 2), tHb, COHb, and MetHb non-invasively. Multiwavelength LED (600, 625, 660, 760, 800, 940, and 1300 nm) and a combined detector (Si, InGaAs) were built into the instrument (Seven wavelengths transparent pulse spectrophotometer). We used the Waseda mock circulatory system, which can simulate blood circulation in tissues and generate a pulse wave mechanically, to estimate the instrument's performance. Furthermore we proposed new calculation formula including DC components of optical density (this method). Under conditions without any change of other components, the mean error ± standard deviation between this method and the CO-oximetry were SaO 2=0.0±1.4%, tHb=0.0±0.0 g/dl, COHb=0.0±2.0%, and MetHb=0.0±0.3%. When the concentration of other components was changed, this method showed mean errors and standard deviations of SaO 2=0.2±1.6%, tHb=0.0±0.4 g/dl, COHb=0.5±4.1%, and MetHb=0.0±0.3%.

Original languageEnglish
Title of host publication28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Pages799-802
Number of pages4
DOIs
Publication statusPublished - 2006 Dec 1
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: 2006 Aug 302006 Sep 3

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)0589-1019

Conference

Conference28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period06/8/3006/9/3

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Fingerprint Dive into the research topics of 'Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system-'. Together they form a unique fingerprint.

  • Cite this

    Suzaki, H., Kobayashi, N., Nagaoka, T., Iwasaki, K., Umezu, M., Takeda, S., & Togawa, T. (2006). Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system-. In 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 (pp. 799-802). [4029808] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). https://doi.org/10.1109/IEMBS.2006.260273