Novel chemoembolization using calcium-phosphate ceramic microsphere incorporating TNP-470, an anti-angiogenic agent

Makoto Emoto, Yasuko Naganuma, Batsuren Choijamts, Toshiki Ohno, Hajime Yoshihisa, Nobuhiro Kanomata, Tatsuhiko Kawarabayashi, Mamoru Aizawa

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    The purpose of the present study was to develop a new method of chemoembolization to improve the therapeutic effectiveness and safety profile of cancer treatment. A chemoembolization approach was designed for human solid tumors using resorbable calcium-phosphate ceramic microspheres loaded with an agent anti-angiogenic to tumor vasculature in vivo. The human uterine sarcoma cell line FU-MMT-3 was used in this study because this tumor is aggressive and also exhibits a poor response to radiotherapy or any chemotherapy currently used. The calcium-phosphate ceramic microspheres loaded with TNP-470, an anti-angiogenic agent, were injected into FU-MMT-3 xenografts in nude mice three times per week for 8weeks. The treatment using TNP-470-loaded microspheres suppressed tumor growth, compared to treatment with TNP-470 alone, microspheres alone, and the control. The mean tumor weight after treatment using TNP-470-loaded microspheres was significantly lower than that after treatment with microspheres alone. These ceramic microspheres were remarkably embolized in tumor microvessels as well as in the feeding arteries and a significant reduction of intratumoral vascularity was also demonstrated following treatment with TNP-470-loaded microspheres. Severe loss of body weight was not observed in any mice treated with the TNP-470-loaded microspheres, compared to treatment with TNP-470 alone. These results suggest that targeting tumor vasculature in human uterine sarcoma using calcium-phosphate microspheres might be more effective and safer than the treatment that employs anti-angiogenic agent alone. This new chemoembolization method incorporating an anti-angiogenic agent may contribute to the effective treatment of locally advanced or recurrent solid tumors.

    Original languageEnglish
    Pages (from-to)984-990
    Number of pages7
    JournalCancer Science
    Volume101
    Issue number4
    DOIs
    Publication statusPublished - 2010 Apr

    Fingerprint

    Ceramics
    Microspheres
    Neoplasms
    Therapeutics
    Sarcoma
    O-(chloroacetylcarbamoyl)fumagillol
    calcium phosphate
    Microvessels
    Tumor Burden
    Heterografts
    Nude Mice
    Radiotherapy
    Arteries
    Body Weight
    Safety
    Drug Therapy
    Cell Line

    ASJC Scopus subject areas

    • Cancer Research
    • Oncology

    Cite this

    Novel chemoembolization using calcium-phosphate ceramic microsphere incorporating TNP-470, an anti-angiogenic agent. / Emoto, Makoto; Naganuma, Yasuko; Choijamts, Batsuren; Ohno, Toshiki; Yoshihisa, Hajime; Kanomata, Nobuhiro; Kawarabayashi, Tatsuhiko; Aizawa, Mamoru.

    In: Cancer Science, Vol. 101, No. 4, 04.2010, p. 984-990.

    Research output: Contribution to journalArticle

    Emoto, M, Naganuma, Y, Choijamts, B, Ohno, T, Yoshihisa, H, Kanomata, N, Kawarabayashi, T & Aizawa, M 2010, 'Novel chemoembolization using calcium-phosphate ceramic microsphere incorporating TNP-470, an anti-angiogenic agent', Cancer Science, vol. 101, no. 4, pp. 984-990. https://doi.org/10.1111/j.1349-7006.2009.01479.x
    Emoto, Makoto ; Naganuma, Yasuko ; Choijamts, Batsuren ; Ohno, Toshiki ; Yoshihisa, Hajime ; Kanomata, Nobuhiro ; Kawarabayashi, Tatsuhiko ; Aizawa, Mamoru. / Novel chemoembolization using calcium-phosphate ceramic microsphere incorporating TNP-470, an anti-angiogenic agent. In: Cancer Science. 2010 ; Vol. 101, No. 4. pp. 984-990.
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