Novel clusters of highly expressed genes accompany genomic amplification in breast cancers

Emi Ito, Reiko Honma, Yuka Yanagisawa, Jun ichi Imai, Sakura Azuma, Tetsunari Oyama, Susumu Ohwada, Tetsu Akiyama, Nobuo Nomura, Jun ichiro Inoue, Shinya Watanabe, Kentaro Semba

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12 Citations (Scopus)

Abstract

Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.

Original languageEnglish
Pages (from-to)3909-3914
Number of pages6
JournalFEBS Letters
Volume581
Issue number21
DOIs
Publication statusPublished - 2007 Aug 21

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Keywords

  • Breast cancer
  • Gene amplification
  • Microarray

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Ito, E., Honma, R., Yanagisawa, Y., Imai, J. I., Azuma, S., Oyama, T., Ohwada, S., Akiyama, T., Nomura, N., Inoue, J. I., Watanabe, S., & Semba, K. (2007). Novel clusters of highly expressed genes accompany genomic amplification in breast cancers. FEBS Letters, 581(21), 3909-3914. https://doi.org/10.1016/j.febslet.2007.07.016