Novel clusters of highly expressed genes accompany genomic amplification in breast cancers

Emi Ito, Reiko Honma, Yuka Yanagisawa, Jun ichi Imai, Sakura Azuma, Tetsunari Oyama, Susumu Ohwada, Tetsu Akiyama, Nobuo Nomura, Jun ichiro Inoue, Shinya Watanabe, Kentaro Senba

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.

    Original languageEnglish
    Pages (from-to)3909-3914
    Number of pages6
    JournalFEBS Letters
    Volume581
    Issue number21
    DOIs
    Publication statusPublished - 2007 Aug 21

    Fingerprint

    Chromosomes
    Amplification
    Genes
    Breast Neoplasms
    Gene expression
    Chromosomes, Human, Pair 8
    Chromosomes, Human, Pair 17
    Cells
    Multigene Family
    Southern Blotting
    Carcinogenesis
    Breast
    Phenotype
    Gene Expression
    Cell Line
    Neoplasms
    Therapeutics

    Keywords

    • Breast cancer
    • Gene amplification
    • Microarray

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

    Cite this

    Novel clusters of highly expressed genes accompany genomic amplification in breast cancers. / Ito, Emi; Honma, Reiko; Yanagisawa, Yuka; Imai, Jun ichi; Azuma, Sakura; Oyama, Tetsunari; Ohwada, Susumu; Akiyama, Tetsu; Nomura, Nobuo; Inoue, Jun ichiro; Watanabe, Shinya; Senba, Kentaro.

    In: FEBS Letters, Vol. 581, No. 21, 21.08.2007, p. 3909-3914.

    Research output: Contribution to journalArticle

    Ito, E, Honma, R, Yanagisawa, Y, Imai, JI, Azuma, S, Oyama, T, Ohwada, S, Akiyama, T, Nomura, N, Inoue, JI, Watanabe, S & Senba, K 2007, 'Novel clusters of highly expressed genes accompany genomic amplification in breast cancers', FEBS Letters, vol. 581, no. 21, pp. 3909-3914. https://doi.org/10.1016/j.febslet.2007.07.016
    Ito E, Honma R, Yanagisawa Y, Imai JI, Azuma S, Oyama T et al. Novel clusters of highly expressed genes accompany genomic amplification in breast cancers. FEBS Letters. 2007 Aug 21;581(21):3909-3914. https://doi.org/10.1016/j.febslet.2007.07.016
    Ito, Emi ; Honma, Reiko ; Yanagisawa, Yuka ; Imai, Jun ichi ; Azuma, Sakura ; Oyama, Tetsunari ; Ohwada, Susumu ; Akiyama, Tetsu ; Nomura, Nobuo ; Inoue, Jun ichiro ; Watanabe, Shinya ; Senba, Kentaro. / Novel clusters of highly expressed genes accompany genomic amplification in breast cancers. In: FEBS Letters. 2007 ; Vol. 581, No. 21. pp. 3909-3914.
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