Novel clusters of highly expressed genes accompany genomic amplification in breast cancers

Emi Ito; Reiko Honma; Yuka Yanagisawa; Jun ichi Imai; Sakura Azuma; Tetsunari Oyama; Susumu Ohwada; Tetsu Akiyama; Nobuo Nomura; Jun ichiro Inoue; Shinya Watanabe; Kentaro Semba

doi:10.1016/j.febslet.2007.07.016

Novel clusters of highly expressed genes accompany genomic amplification in breast cancers

Emi Ito, Reiko Honma, Yuka Yanagisawa, Jun ichi Imai, Sakura Azuma, Tetsunari Oyama, Susumu Ohwada, Tetsu Akiyama, Nobuo Nomura, Jun ichiro Inoue, Shinya Watanabe, Kentaro Semba^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.

Original language	English
Pages (from-to)	3909-3914
Number of pages	6
Journal	FEBS Letters
Volume	581
Issue number	21
DOIs	https://doi.org/10.1016/j.febslet.2007.07.016
Publication status	Published - 2007 Aug 21

Keywords

Breast cancer
Gene amplification
Microarray

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2007.07.016

Cite this

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title = "Novel clusters of highly expressed genes accompany genomic amplification in breast cancers",

abstract = "Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.",

keywords = "Breast cancer, Gene amplification, Microarray",

author = "Emi Ito and Reiko Honma and Yuka Yanagisawa and Imai, {Jun ichi} and Sakura Azuma and Tetsunari Oyama and Susumu Ohwada and Tetsu Akiyama and Nobuo Nomura and Inoue, {Jun ichiro} and Shinya Watanabe and Kentaro Semba",

note = "Funding Information: We thank M. Hashimoto for the secretarial assistance. This work was supported in part by the “Establishment of Consolidated Research Institute for Advanced Science and Medical Care”; Encouraging Development Strategic Research Centers Program, Ministry of Education, Culture, Sports, Science and Technology, Japan; and New Energy and Industrial Technology Development Organization (NEDO). ",

year = "2007",

month = aug,

day = "21",

doi = "10.1016/j.febslet.2007.07.016",

language = "English",

volume = "581",

pages = "3909--3914",

journal = "FEBS Letters",

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publisher = "Elsevier",

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T1 - Novel clusters of highly expressed genes accompany genomic amplification in breast cancers

AU - Ito, Emi

AU - Honma, Reiko

AU - Yanagisawa, Yuka

AU - Imai, Jun ichi

AU - Azuma, Sakura

AU - Oyama, Tetsunari

AU - Ohwada, Susumu

AU - Akiyama, Tetsu

AU - Nomura, Nobuo

AU - Inoue, Jun ichiro

AU - Watanabe, Shinya

AU - Semba, Kentaro

N1 - Funding Information: We thank M. Hashimoto for the secretarial assistance. This work was supported in part by the “Establishment of Consolidated Research Institute for Advanced Science and Medical Care”; Encouraging Development Strategic Research Centers Program, Ministry of Education, Culture, Sports, Science and Technology, Japan; and New Energy and Industrial Technology Development Organization (NEDO).

PY - 2007/8/21

Y1 - 2007/8/21

N2 - Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.

AB - Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.

KW - Breast cancer

KW - Gene amplification

KW - Microarray

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SN - 0014-5793

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JO - FEBS Letters

JF - FEBS Letters

IS - 21

ER -

Novel clusters of highly expressed genes accompany genomic amplification in breast cancers

Abstract

Keywords

ASJC Scopus subject areas

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