Novel concepts for organic syntheses based on interfaces and molecular machines

Shinsuke Ishihara, Yutaka Wakayama, Nobuya Hiroshiba, Jonathan P. Hill, Katsuhiko Ariga*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Without doubt, organic chemistry has made significant contributions in improving the qualities of our lives. However, there exists a demand for well-designed molecules of complex structures with additional requirements for low-cost and low-energy production of the materials, which stimulate us to consider innovative concepts in organic synthetic methods. In order to propose innovative methods for next-generation organic synthetic procedures, we present two strategies, (i) organic synthesis within two-dimensional molecular patterns and (ii) organic synthesis driven by molecular machines working at interfaces. For example, synthesis of stereo-regulated polymeric materials in two-dimensional molecular arrays, tip-induced chemical reactions at a solid surface, sequential reactions guided by polymer chains, DNA-nanorobots on two-dimensional DNA origami, ester hydrolysis based on modified behavior of protonated amines at an interface, and several other methods are introduced as pioneering and innovative concepts.

Original languageEnglish
Pages (from-to)428-438
Number of pages11
JournalCurrent Organic Synthesis
Issue number4
Publication statusPublished - 2012 Aug 9
Externally publishedYes


  • DNA Origami
  • Interface
  • Molecular Machine
  • Molecular Pattern
  • Molecular Recognition
  • Surface

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry


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