Novel metabolic pathway for salicylate biodegradation via phenol in yeast Trichosporon moniliiforme

Yuichiro Iwasaki, Hiroaki Gunji, Kuniki Kino, Takasumi Hattori, Yoshitaka Ishii, Kotaro Kirimura

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    A novel metabolic pathway was found in the yeast Trichosporon moniliiforme WU-0401 for salicylate degradation via phenol as the key intermediate. When 20 mM salicylate was used as the sole carbon source for the growth of strain WU-0401, phenol was detected as a distinct metabolite in the culture broth. Analysis of the products derived from salicylate or phenol through reactions with resting cells and a cell-free extract of strain WU-0401 indicated that salicylate is initially decarboxylated to phenol and then oxidized to catechol, followed by aromatic ring cleavage to form cis-cis muconate.

    Original languageEnglish
    Pages (from-to)557-564
    Number of pages8
    JournalBiodegradation
    Volume21
    Issue number4
    DOIs
    Publication statusPublished - 2010 Jul

    Fingerprint

    Trichosporon
    salicylate
    Salicylates
    Metabolic Networks and Pathways
    Phenol
    Biodegradation
    Yeast
    Phenols
    yeast
    phenol
    biodegradation
    Yeasts
    Metabolites
    Cell Extracts
    cleavage
    metabolite
    Carbon
    Degradation
    degradation
    carbon

    Keywords

    • Biodegradation
    • Metabolic pathway
    • Phenol
    • Salicylate
    • Trichosporon moniliiforme

    ASJC Scopus subject areas

    • Environmental Engineering
    • Pollution
    • Environmental Chemistry
    • Microbiology
    • Bioengineering

    Cite this

    Novel metabolic pathway for salicylate biodegradation via phenol in yeast Trichosporon moniliiforme. / Iwasaki, Yuichiro; Gunji, Hiroaki; Kino, Kuniki; Hattori, Takasumi; Ishii, Yoshitaka; Kirimura, Kotaro.

    In: Biodegradation, Vol. 21, No. 4, 07.2010, p. 557-564.

    Research output: Contribution to journalArticle

    Iwasaki, Yuichiro ; Gunji, Hiroaki ; Kino, Kuniki ; Hattori, Takasumi ; Ishii, Yoshitaka ; Kirimura, Kotaro. / Novel metabolic pathway for salicylate biodegradation via phenol in yeast Trichosporon moniliiforme. In: Biodegradation. 2010 ; Vol. 21, No. 4. pp. 557-564.
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    AU - Kirimura, Kotaro

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