Novel pyridine-formation reactions of 2-(phosphoranylideneamino)acrylaldehydes with acetylenic esters. Synthesis of 2-mono-and 2,5-disubstituted nicotinates

Nobuhiro Kanomata, Tadashi Nakata

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Preparation of 2-(phosphoranylideneamino)acrylaldehydes, novel formyl-substituted (vinylimino)phosphoranes, was accomplished by the reaction of formyl-2H-azirines with triphenylphosphine. Their novel pyridine-formation reactions with acetylenic esters achieved the preferential formation of 2-mono- and 2,5-disubstituted nicotinate derivatives.

Original languageEnglish
Pages (from-to)2551-2558
Number of pages8
JournalHeterocycles
Volume48
Issue number12
DOIs
Publication statusPublished - 1998 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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