Novel therapeutic use of polysaccharide nanosheets for arachnoid plasty and enhancement of venous tensile strength in rat microneurosurgery

Naoki Otani, Manabu Kinoshita, Toshinori Fujie, Akihiro Saito, Shinji Takeoka, Daizoh Saitoh, Kohsuke Hagisawa, Hiroshi Nawashiro, Katsuji Shima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Subdural effusion sometimes occurs during neurosurgery after opening the Sylvian fissure, due to cerebrospinal fluid (CSF) leakage from the torn arachnoid membrane. Unexpected bleeding from the fragile bridging veins may also result from brain retraction. Neurosurgeons must always watch carefully for these complications during surgery. To prevent such complications, we have attempted the clinical application of a polysaccharide nanosheet that is semi-absorbent and has a potent physical adhesive strength to investigate its therapeutic utility for arachnoid plasty and enhancement of bridging vein tensile strength in Sprague-Dawley rats. The use of overlapping nanosheets completely prevented CSF leakage from injured arachnoid membranes in the cerebral cortex. No inflammatory infiltration was observed on the cerebral surface after 6 months of follow up. In addition, the use of nanosheet bandages significantly reinforced venous tensile strength. This reinforcement increased with the number of overlaid nanosheets. We report that polysaccharide nanosheets can be used for arachnoid plasty without chemical bonding agents and for reinforcement of venous tensile strength in rat vessels. Nanosheets may be an effective neurosurgical tool.

Original languageEnglish
Pages (from-to)301-305
Number of pages5
JournalJournal of Clinical Neuroscience
Volume20
Issue number2
DOIs
Publication statusPublished - 2013 Feb

Fingerprint

Arachnoid
Tensile Strength
Therapeutic Uses
Polysaccharides
Veins
Subdural Effusion
Membranes
Neurosurgery
Bandages
Adhesives
Cerebral Cortex
Sprague Dawley Rats
Hemorrhage
Brain
Cerebrospinal Fluid Leak

Keywords

  • Arachnoid plasty
  • Microneurosurgery
  • Nanosheets

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)

Cite this

Novel therapeutic use of polysaccharide nanosheets for arachnoid plasty and enhancement of venous tensile strength in rat microneurosurgery. / Otani, Naoki; Kinoshita, Manabu; Fujie, Toshinori; Saito, Akihiro; Takeoka, Shinji; Saitoh, Daizoh; Hagisawa, Kohsuke; Nawashiro, Hiroshi; Shima, Katsuji.

In: Journal of Clinical Neuroscience, Vol. 20, No. 2, 02.2013, p. 301-305.

Research output: Contribution to journalArticle

Otani, Naoki ; Kinoshita, Manabu ; Fujie, Toshinori ; Saito, Akihiro ; Takeoka, Shinji ; Saitoh, Daizoh ; Hagisawa, Kohsuke ; Nawashiro, Hiroshi ; Shima, Katsuji. / Novel therapeutic use of polysaccharide nanosheets for arachnoid plasty and enhancement of venous tensile strength in rat microneurosurgery. In: Journal of Clinical Neuroscience. 2013 ; Vol. 20, No. 2. pp. 301-305.
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