NRPSs and amide ligases producing homopoly(amino acid)s and homooligo(amino acid)s

Yoshimitsu Hamano, Toshinobu Arai, Makoto Ashiuchi, Kuniki Kino

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Covering: 1943 to 2013 Microorganisms are capable of producing a wide variety of biopolymers. Homopoly(amino acid)s and homooligo(amino acid)s, which are made up of only a single type of amino acid, are relatively rare; in fact, only two homopoly(amino acid)s have been known to occur in nature: poly(ε-l-lysine) (ε-PL) and poly(γ-glutamic acid) (γ-PGA). Bacterial enzymes that produce homooligo(amino acid)s, such as l-β-lysine-, l-valine-, l-leucine-, l-isoleucine-, l-methionine-, and l-glutamic acid-oligopeptides and poly(α-l-glutamic acid) (α-PGA) have recently been identified, as well as ε-PL synthetase and γ-PGA synthetase. This article reviews the current knowledge about these unique enzymes producing homopoly(amino acid)s and homooligo(amino acid)s.

    Original languageEnglish
    Pages (from-to)1087-1097
    Number of pages11
    JournalNatural Product Reports
    Volume30
    Issue number8
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Ligases
    Amides
    Amino Acids
    Prostaglandins A
    Lysine
    Glutamic Acid
    Oligopeptides
    Biopolymers
    Isoleucine
    Valine
    Enzymes
    Leucine
    Methionine
    Microorganisms

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery
    • Medicine(all)

    Cite this

    NRPSs and amide ligases producing homopoly(amino acid)s and homooligo(amino acid)s. / Hamano, Yoshimitsu; Arai, Toshinobu; Ashiuchi, Makoto; Kino, Kuniki.

    In: Natural Product Reports, Vol. 30, No. 8, 2013, p. 1087-1097.

    Research output: Contribution to journalArticle

    Hamano, Yoshimitsu ; Arai, Toshinobu ; Ashiuchi, Makoto ; Kino, Kuniki. / NRPSs and amide ligases producing homopoly(amino acid)s and homooligo(amino acid)s. In: Natural Product Reports. 2013 ; Vol. 30, No. 8. pp. 1087-1097.
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