Nucleobase self-assembly in supramolecular adhesives

Shijing Cheng, Mingqiang Zhang, Ninad Dixit, Robert B. Moore, Timothy Edward Long

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Novel acrylic monomers functionalized with nucleobase-containing units (adenine and thymine) were prepared upon aza-Michael addition and successfully copolymerized with n-butyl acrylate. At a content of 7 mol %, adenine-containing units self-assembled into needle-like microstructures within amorphous polymer matrices as shown with atomic force microscopy (AFM), small-angle X-ray scattering (SAXS), and wide-angle X-ray diffraction (WAXD); thymine-containing units did not aggregate into distinct morphologies even to 30 mol %. Upon blending, thymine- and adenine-containing statistical copolymers associated into a thermodynamically stable complex, which was physically cross-linked through adenine-thymine base pairing. The molar fractions of the nucleobase monomer, nucleobase stacking interactions, and complementary hydrogen bonding principally influenced self-assembly. Additionally, the nucleobase-functionalized polyacrylates exhibited tunable adhesive and cohesive strength.

Original languageEnglish
Pages (from-to)805-812
Number of pages8
JournalMacromolecules
Volume45
Issue number2
DOIs
Publication statusPublished - 2012 Jan 24
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry

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  • Cite this

    Cheng, S., Zhang, M., Dixit, N., Moore, R. B., & Long, T. E. (2012). Nucleobase self-assembly in supramolecular adhesives. Macromolecules, 45(2), 805-812. https://doi.org/10.1021/ma202122r