Nucleotide sequence and chromosomal mapping of the human c-yes-2 gene

Kentaro Senba, Makoto Nishizawa, Hitoshi Satoh, Shin ichi Fukushige, Michihiro C. Yoshida, Motomichi Sasaki, Ken ichi Matsubara, Tadashi Yamamoto, Kumao Toyoshima

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We molecularly characterized the second gene, c-yes-2, of two copies of yes-related genes which we previously found to contain in the human genome. First, nucleotide sequence analysis revealed that the c-yes-2 gene is a pseudogene of the c-yes-1 gene. Second, by using two independent methods, hybridization of both DNAs from sorted chromosomes and metaphase spreads with c-yes-2 DNA, we assigned the c-yes-2 gene to chromosome 22q11.2. This chromosomal localization is inconsistent with that given in our previous report. The failure of proper mapping in our experiment might have been caused by instability of hybrid cell clones.

Original languageEnglish
Pages (from-to)710-717
Number of pages8
JournalJapanese Journal of Cancer Research
Volume79
Issue number6
Publication statusPublished - 1988 Jun
Externally publishedYes

Fingerprint

Genes
Chromosomes
Pseudogenes
Hybrid Cells
DNA
Human Genome
Metaphase
Sequence Analysis
Clone Cells

Keywords

  • c-yes-2
  • Chromosome 22
  • Pseudogene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Senba, K., Nishizawa, M., Satoh, H., Fukushige, S. I., Yoshida, M. C., Sasaki, M., ... Toyoshima, K. (1988). Nucleotide sequence and chromosomal mapping of the human c-yes-2 gene. Japanese Journal of Cancer Research, 79(6), 710-717.

Nucleotide sequence and chromosomal mapping of the human c-yes-2 gene. / Senba, Kentaro; Nishizawa, Makoto; Satoh, Hitoshi; Fukushige, Shin ichi; Yoshida, Michihiro C.; Sasaki, Motomichi; Matsubara, Ken ichi; Yamamoto, Tadashi; Toyoshima, Kumao.

In: Japanese Journal of Cancer Research, Vol. 79, No. 6, 06.1988, p. 710-717.

Research output: Contribution to journalArticle

Senba, K, Nishizawa, M, Satoh, H, Fukushige, SI, Yoshida, MC, Sasaki, M, Matsubara, KI, Yamamoto, T & Toyoshima, K 1988, 'Nucleotide sequence and chromosomal mapping of the human c-yes-2 gene', Japanese Journal of Cancer Research, vol. 79, no. 6, pp. 710-717.
Senba K, Nishizawa M, Satoh H, Fukushige SI, Yoshida MC, Sasaki M et al. Nucleotide sequence and chromosomal mapping of the human c-yes-2 gene. Japanese Journal of Cancer Research. 1988 Jun;79(6):710-717.
Senba, Kentaro ; Nishizawa, Makoto ; Satoh, Hitoshi ; Fukushige, Shin ichi ; Yoshida, Michihiro C. ; Sasaki, Motomichi ; Matsubara, Ken ichi ; Yamamoto, Tadashi ; Toyoshima, Kumao. / Nucleotide sequence and chromosomal mapping of the human c-yes-2 gene. In: Japanese Journal of Cancer Research. 1988 ; Vol. 79, No. 6. pp. 710-717.
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