Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase

Kazuhiko Uchida, Toshiro Morita, Takako Sato, Tsutomu Ogura, Rumiko Yamashita, Shigeru Noguchi, Hisanori Suzuki, Hiroshi Nyunoya, Masanao Miwa, Takashi Sugimura

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted α-helix-turn-α-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3′ untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.

Original languageEnglish
Pages (from-to)617-622
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume148
Issue number2
DOIs
Publication statusPublished - 1987 Oct 29
Externally publishedYes

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Poly(ADP-ribose) Polymerases
Fibroblasts
Nucleotides
Complementary DNA
AT Rich Sequence
Amino Acids
DNA
3' Untranslated Regions
Open Reading Frames
Cysteine
Zinc
Messenger RNA
Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase. / Uchida, Kazuhiko; Morita, Toshiro; Sato, Takako; Ogura, Tsutomu; Yamashita, Rumiko; Noguchi, Shigeru; Suzuki, Hisanori; Nyunoya, Hiroshi; Miwa, Masanao; Sugimura, Takashi.

In: Biochemical and Biophysical Research Communications, Vol. 148, No. 2, 29.10.1987, p. 617-622.

Research output: Contribution to journalArticle

Uchida, K, Morita, T, Sato, T, Ogura, T, Yamashita, R, Noguchi, S, Suzuki, H, Nyunoya, H, Miwa, M & Sugimura, T 1987, 'Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase', Biochemical and Biophysical Research Communications, vol. 148, no. 2, pp. 617-622. https://doi.org/10.1016/0006-291X(87)90921-1
Uchida, Kazuhiko ; Morita, Toshiro ; Sato, Takako ; Ogura, Tsutomu ; Yamashita, Rumiko ; Noguchi, Shigeru ; Suzuki, Hisanori ; Nyunoya, Hiroshi ; Miwa, Masanao ; Sugimura, Takashi. / Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase. In: Biochemical and Biophysical Research Communications. 1987 ; Vol. 148, No. 2. pp. 617-622.
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