Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase

Kazuhiko Uchida, Toshiro Morita, Takako Sato, Tsutomu Ogura, Rumiko Yamashita, Shigeru Noguchi, Hisanori Suzuki, Hiroshi Nyunoya, Masanao Miwa, Takashi Sugimura

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted α-helix-turn-α-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3′ untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.

Original languageEnglish
Pages (from-to)617-622
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume148
Issue number2
DOIs
Publication statusPublished - 1987 Oct 29
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Uchida, K., Morita, T., Sato, T., Ogura, T., Yamashita, R., Noguchi, S., Suzuki, H., Nyunoya, H., Miwa, M., & Sugimura, T. (1987). Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase. Biochemical and Biophysical Research Communications, 148(2), 617-622. https://doi.org/10.1016/0006-291X(87)90921-1