Numerical investigation on nonlinear response of free microbubble illuminated with ultrasound pulse

Kawan Soetanto, Shinichi Takeuchi, Motoyoshi Okujima

Research output: Contribution to journalArticle

2 Citations (Scopus)


Recently, new ultrasound imaging methods and new blood flow-metry using higher harmonics components based on nonlinear behavior of microbubble ultrasound contrast agent are studied. These ultrasound diagnostic equipment using with ultrasound contrast agents can be used to improve the accuracy of blood flow diagnosis and to enhance the image of abnormal tissue like tumors in the ultrasound diagnostic image. In this paper, the results of numerical study on relationship between the ultrasound illuminating condition and higher harmonics components included in scattered wave from free air microbubbles in water is reported to develop such a medical diagnostic equipment using the nonlinear response of microbubble contrast agent. This study is performed for a microbubble with radius larger than 10[μm] suitable to the contrast agent in artery and for a microbubble with radius smaller than 10[μm] suitable to the contrast agent in vein. The nonlinear response of free microbubbles with size distribution is also studied concerning with the random space distribution.

Original languageEnglish
Pages (from-to)169-180
Number of pages12
JournalJournal of the Acoustical Society of Japan (E) (English translation of Nippon Onkyo Gakkaishi)
Issue number3
Publication statusPublished - 1998 Jan 1


ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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