Objective examination for two-point stimulation using a somatosensory oddball paradigm

An MEG study

Kosuke Akatsuka, Toshiaki Wasaka, Hiroki Nakata, Tetsuo Kida, Minoru Hoshiyama, Yohei Tamura, Ryusuke Kakigi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective: To establish an objective two-point discrimination test using magnetoencephalography (MEG). Methods: First, we determined the discrimination threshold (DT) of the two-points. In the first experiment, we applied 0.9DT as standard stimuli, and 0.8DT, 1.1DT and 2DT as deviant stimuli in Conditions 1, 2 and 3, respectively. In the second experiment, we used 2DT and 0.9DT as the standard and deviant stimuli, respectively, in Condition 1. We applied two-stimuli that subjects felt as definitely one point or two-points in Condition 2 and 3, respectively. Results: In the first experiment, the components peaking around 30-70 and 150-250 ms following deviant stimuli were significantly larger than those following standard stimuli. Considering the peak latency, these components seem consistent with the magnetic mismatch field (MMF). In the second experiment, the MMF was recorded only in Condition 1. Therefore, it is considered that the MMF was recorded only when subjects automatically discriminate one point from two-points stimuli. Conclusions: This novel method can be used in neurophysiological two-point discrimination tests without the need to rely on the examiners' skills and subjects' reactions. Significance: We confirmed that our new method could be used for the objective examination of two-point spatial discrimination.

Original languageEnglish
Pages (from-to)403-411
Number of pages9
JournalClinical Neurophysiology
Volume118
Issue number2
DOIs
Publication statusPublished - 2007 Feb

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Magnetoencephalography
Magnetic Fields

Keywords

  • Magnetoencephalography
  • Mismatch field
  • Somatosensory
  • Spatial discrimination
  • Two-point discrimination

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Akatsuka, K., Wasaka, T., Nakata, H., Kida, T., Hoshiyama, M., Tamura, Y., & Kakigi, R. (2007). Objective examination for two-point stimulation using a somatosensory oddball paradigm: An MEG study. Clinical Neurophysiology, 118(2), 403-411. https://doi.org/10.1016/j.clinph.2006.09.030

Objective examination for two-point stimulation using a somatosensory oddball paradigm : An MEG study. / Akatsuka, Kosuke; Wasaka, Toshiaki; Nakata, Hiroki; Kida, Tetsuo; Hoshiyama, Minoru; Tamura, Yohei; Kakigi, Ryusuke.

In: Clinical Neurophysiology, Vol. 118, No. 2, 02.2007, p. 403-411.

Research output: Contribution to journalArticle

Akatsuka, K, Wasaka, T, Nakata, H, Kida, T, Hoshiyama, M, Tamura, Y & Kakigi, R 2007, 'Objective examination for two-point stimulation using a somatosensory oddball paradigm: An MEG study', Clinical Neurophysiology, vol. 118, no. 2, pp. 403-411. https://doi.org/10.1016/j.clinph.2006.09.030
Akatsuka, Kosuke ; Wasaka, Toshiaki ; Nakata, Hiroki ; Kida, Tetsuo ; Hoshiyama, Minoru ; Tamura, Yohei ; Kakigi, Ryusuke. / Objective examination for two-point stimulation using a somatosensory oddball paradigm : An MEG study. In: Clinical Neurophysiology. 2007 ; Vol. 118, No. 2. pp. 403-411.
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