On-chip cellomics assay: Artificial re-construction of tissue model for cell based drug discovery

Research output: Contribution to conferencePaper

Abstract

We began a series of studies aimed at developing methods and systems of analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. The role of epigenetic information on cells, which complements their genetic information, was inferred by comparing predictions from genetic information with cell behaviour observed under conditions chosen to reveal adaptation processes and community effects. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). The knowlege acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.

Original languageEnglish
Pages1070-1075
Number of pages6
Publication statusPublished - 2006 Jan 1
Externally publishedYes
Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
Duration: 2006 Nov 52006 Nov 9

Conference

Conference10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
CountryJapan
CityTokyo
Period06/11/506/11/9

Keywords

  • Adaptation
  • Agarose microchamber array
  • Algebraic viewpoint
  • Epigenetic information
  • Geometric viewpoint
  • Individuality
  • Inheritance
  • Multielectrode array (MEA)
  • On-chip cellomics assay
  • Photo-thermal etching
  • Synchronization
  • Variability

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Yasuda, K. (2006). On-chip cellomics assay: Artificial re-construction of tissue model for cell based drug discovery. 1070-1075. Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.