On-chip cellomics assay: Artificial re-construction of tissue model for cell based drug discovery

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We began a series of studies aimed at developing methods and systems of analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. The role of epigenetic information on cells, which complements their genetic information, was inferred by comparing predictions from genetic information with cell behaviour observed under conditions chosen to reveal adaptation processes and community effects. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). The knowlege acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.

Original languageEnglish
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2006 Conference: 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherJapan Academic Association Inc
Pages1070-1075
Number of pages6
Publication statusPublished - 2006
Externally publishedYes
Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo
Duration: 2006 Nov 52006 Nov 9

Other

Other10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
CityTokyo
Period06/11/506/11/9

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Keywords

  • Adaptation
  • Agarose microchamber array
  • Algebraic viewpoint
  • Epigenetic information
  • Geometric viewpoint
  • Individuality
  • Inheritance
  • Multielectrode array (MEA)
  • On-chip cellomics assay
  • Photo-thermal etching
  • Synchronization
  • Variability

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Yasuda, K. (2006). On-chip cellomics assay: Artificial re-construction of tissue model for cell based drug discovery. In Micro Total Analysis Systems - Proceedings of MicroTAS 2006 Conference: 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1070-1075). Japan Academic Association Inc.