On-chip cellomics

Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We have developed methods and systems of analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). As an example of the 'geometric' system, we have developed an quasi-in vivo hiPS cardiomyocyte network assay and confirmed that it can predict the risk of lethal arrythmia correctly in 22 compounds. The knowlege acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.

Original languageEnglish
Title of host publication2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Pages2825-2828
Number of pages4
DOIs
Publication statusPublished - 2013
Externally publishedYes
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
Duration: 2013 Jul 32013 Jul 7

Other

Other2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
CountryJapan
CityOsaka
Period13/7/313/7/7

Fingerprint

Assays
Screening
Epigenomics
Preclinical Drug Evaluations
Cardiac Myocytes
Hip
Cardiac Arrhythmias
Regeneration
Cardiotoxicity

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Yasuda, K. (2013). On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 (pp. 2825-2828). [6610128] https://doi.org/10.1109/EMBC.2013.6610128

On-chip cellomics : Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity. / Yasuda, Kenji.

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 2825-2828 6610128.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yasuda, K 2013, On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity. in 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013., 6610128, pp. 2825-2828, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 13/7/3. https://doi.org/10.1109/EMBC.2013.6610128
Yasuda K. On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 2825-2828. 6610128 https://doi.org/10.1109/EMBC.2013.6610128
Yasuda, Kenji. / On-chip cellomics : Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. pp. 2825-2828
@inproceedings{fb414c42899043519602caf96c95822e,
title = "On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity",
abstract = "We have developed methods and systems of analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). As an example of the 'geometric' system, we have developed an quasi-in vivo hiPS cardiomyocyte network assay and confirmed that it can predict the risk of lethal arrythmia correctly in 22 compounds. The knowlege acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.",
author = "Kenji Yasuda",
year = "2013",
doi = "10.1109/EMBC.2013.6610128",
language = "English",
isbn = "9781457702167",
pages = "2825--2828",
booktitle = "2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013",

}

TY - GEN

T1 - On-chip cellomics

T2 - Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity

AU - Yasuda, Kenji

PY - 2013

Y1 - 2013

N2 - We have developed methods and systems of analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). As an example of the 'geometric' system, we have developed an quasi-in vivo hiPS cardiomyocyte network assay and confirmed that it can predict the risk of lethal arrythmia correctly in 22 compounds. The knowlege acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.

AB - We have developed methods and systems of analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). As an example of the 'geometric' system, we have developed an quasi-in vivo hiPS cardiomyocyte network assay and confirmed that it can predict the risk of lethal arrythmia correctly in 22 compounds. The knowlege acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.

UR - http://www.scopus.com/inward/record.url?scp=84886497081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886497081&partnerID=8YFLogxK

U2 - 10.1109/EMBC.2013.6610128

DO - 10.1109/EMBC.2013.6610128

M3 - Conference contribution

SN - 9781457702167

SP - 2825

EP - 2828

BT - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013

ER -