Abstract
Limitation of conventional human Ether-a-go-go Related Gene (hERG) assay and QT prolongation testing for accurate prediction of Torsades de Pointes (TdP) by compounds showed us the necessity of a new approach to evaluate global cardiac safety. As one of the advanced applications of an on-chip cellomics system, on-chip cardiomyocyte cell network-based re-entry model assay has the potential to measure the TdP probability as a pre-clinical test for cardiac safety. This system also can estimate the heart pressure, Na, K, and Ca ion channel conditions using a single cell-based optical/electrical measurement system. In this presentation, we present the system setup and then its possible application for drug discovery and toxicology.
| Original language | English |
|---|---|
| Pages (from-to) | 545-557 |
| Number of pages | 13 |
| Journal | Yakugaku Zasshi |
| Volume | 130 |
| Issue number | 4 |
| Publication status | Published - 2010 Apr |
| Externally published | Yes |
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Keywords
- On-chip cellomics
- On-chip re-entry model
- Torsades de Pointes (TdP)
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
Cite this
On-chip cellomics technology for drug screening system using cardiomyocyte cells from human stem cell. / Yasuda, Kenji.
In: Yakugaku Zasshi, Vol. 130, No. 4, 04.2010, p. 545-557.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - On-chip cellomics technology for drug screening system using cardiomyocyte cells from human stem cell
AU - Yasuda, Kenji
PY - 2010/4
Y1 - 2010/4
N2 - Limitation of conventional human Ether-a-go-go Related Gene (hERG) assay and QT prolongation testing for accurate prediction of Torsades de Pointes (TdP) by compounds showed us the necessity of a new approach to evaluate global cardiac safety. As one of the advanced applications of an on-chip cellomics system, on-chip cardiomyocyte cell network-based re-entry model assay has the potential to measure the TdP probability as a pre-clinical test for cardiac safety. This system also can estimate the heart pressure, Na, K, and Ca ion channel conditions using a single cell-based optical/electrical measurement system. In this presentation, we present the system setup and then its possible application for drug discovery and toxicology.
AB - Limitation of conventional human Ether-a-go-go Related Gene (hERG) assay and QT prolongation testing for accurate prediction of Torsades de Pointes (TdP) by compounds showed us the necessity of a new approach to evaluate global cardiac safety. As one of the advanced applications of an on-chip cellomics system, on-chip cardiomyocyte cell network-based re-entry model assay has the potential to measure the TdP probability as a pre-clinical test for cardiac safety. This system also can estimate the heart pressure, Na, K, and Ca ion channel conditions using a single cell-based optical/electrical measurement system. In this presentation, we present the system setup and then its possible application for drug discovery and toxicology.
KW - On-chip cellomics
KW - On-chip re-entry model
KW - Torsades de Pointes (TdP)
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M3 - Review article
VL - 130
SP - 545
EP - 557
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 4
ER -