On-chip cellomics technology for drug screening system using cardiomyocyte cells from human stem cell

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Limitation of conventional human Ether-a-go-go Related Gene (hERG) assay and QT prolongation testing for accurate prediction of Torsades de Pointes (TdP) by compounds showed us the necessity of a new approach to evaluate global cardiac safety. As one of the advanced applications of an on-chip cellomics system, on-chip cardiomyocyte cell network-based re-entry model assay has the potential to measure the TdP probability as a pre-clinical test for cardiac safety. This system also can estimate the heart pressure, Na, K, and Ca ion channel conditions using a single cell-based optical/electrical measurement system. In this presentation, we present the system setup and then its possible application for drug discovery and toxicology.

Original languageEnglish
Pages (from-to)545-557
Number of pages13
JournalYakugaku Zasshi
Volume130
Issue number4
Publication statusPublished - 2010 Apr
Externally publishedYes

Fingerprint

Torsades de Pointes
Preclinical Drug Evaluations
Cardiac Myocytes
Stem Cells
Technology
Safety
Drug Discovery
Ion Channels
Ether
Toxicology
Pressure
Genes

Keywords

  • On-chip cellomics
  • On-chip re-entry model
  • Torsades de Pointes (TdP)

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

On-chip cellomics technology for drug screening system using cardiomyocyte cells from human stem cell. / Yasuda, Kenji.

In: Yakugaku Zasshi, Vol. 130, No. 4, 04.2010, p. 545-557.

Research output: Contribution to journalReview article

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