On-chip gas concentration gradient formation using poreflon™ and NeoFlon™ for in vitro observation of cancer cell

Yu Harada, Kentaro Kawai, Shuichi Shoji

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We propose an in-vitro monitoring device for kinetics and activity of cancer cells in the bone marrow, which can generates a concentration gradient of a gas using hydrophobic-porus microchamber. Pairs of electrodes were used to measure the concentration gradient as the change of electrical resistance of sample solution. The concentration gradient of a gas was successfully measured. When we changed the direction of gas diffusion, we rapidly obtained reverse gradient profile. This concentration gradient can be utilized in biochemical studies including cancer cell monitoring.

    Original languageEnglish
    Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
    Pages551-553
    Number of pages3
    Volume1
    Publication statusPublished - 2010
    Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen
    Duration: 2010 Oct 32010 Oct 7

    Other

    Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
    CityGroningen
    Period10/10/310/10/7

    Fingerprint

    Cells
    Acoustic impedance
    Diffusion in gases
    Monitoring
    Gases
    Bone
    Electrodes
    Kinetics

    Keywords

    • Concentration gradient
    • Microelectrode
    • Neoflon
    • Poreflon

    ASJC Scopus subject areas

    • Control and Systems Engineering

    Cite this

    Harada, Y., Kawai, K., & Shoji, S. (2010). On-chip gas concentration gradient formation using poreflon™ and NeoFlon™ for in vitro observation of cancer cell. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (Vol. 1, pp. 551-553)

    On-chip gas concentration gradient formation using poreflon™ and NeoFlon™ for in vitro observation of cancer cell. / Harada, Yu; Kawai, Kentaro; Shoji, Shuichi.

    14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 1 2010. p. 551-553.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Harada, Y, Kawai, K & Shoji, S 2010, On-chip gas concentration gradient formation using poreflon™ and NeoFlon™ for in vitro observation of cancer cell. in 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. vol. 1, pp. 551-553, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, Groningen, 10/10/3.
    Harada Y, Kawai K, Shoji S. On-chip gas concentration gradient formation using poreflon™ and NeoFlon™ for in vitro observation of cancer cell. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 1. 2010. p. 551-553
    Harada, Yu ; Kawai, Kentaro ; Shoji, Shuichi. / On-chip gas concentration gradient formation using poreflon™ and NeoFlon™ for in vitro observation of cancer cell. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 1 2010. pp. 551-553
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