On-chip gas concentration gradient formation using poreflon™ and NeoFlon™ for in vitro observation of cancer cell

Yu Harada, Kentaro Kawai, Shuichi Shoji

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose an in-vitro monitoring device for kinetics and activity of cancer cells in the bone marrow, which can generates a concentration gradient of a gas using hydrophobic-porus microchamber. Pairs of electrodes were used to measure the concentration gradient as the change of electrical resistance of sample solution. The concentration gradient of a gas was successfully measured. When we changed the direction of gas diffusion, we rapidly obtained reverse gradient profile. This concentration gradient can be utilized in biochemical studies including cancer cell monitoring.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages551-553
Number of pages3
Publication statusPublished - 2010 Dec 1
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume1

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

Keywords

  • Concentration gradient
  • Microelectrode
  • Neoflon
  • Poreflon

ASJC Scopus subject areas

  • Control and Systems Engineering

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    Harada, Y., Kawai, K., & Shoji, S. (2010). On-chip gas concentration gradient formation using poreflon™ and NeoFlon™ for in vitro observation of cancer cell. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 551-553). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 1).