On-chip multichannel action potential recording system for electrical measurement of single neurites of neuronal network

Ikurou Suzuki, Akihiro Hattori, Kenji Yasuda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We have developed a multielectrode array recording system for single-neurite-firing measurement using an artificially constructed neuronal network on a chip, which has a 10 um diameter array with electrodes spaced at 50 μm, for noninvasive 64-channel 100 kHz multirecording and the stimulation of a plurality of neuntes extending from a single neuron. To improve the signal/noise ratio, the ground plane was set on the multi-electrode-array plane and platinum black was set on each of the 10 μm electrodes. Using this system, we performed a multisite recording of neurites of a single neuron of a rat hippocampal network in cases of both spontaneous firing and evoked responses to electrical stimulations, and estimated the velocity of action potential propagation among neurites of a single neuron from six recording sites. This demonstrated the potential use of our low-noise chip and our high-speed measurement system for the analysis of neuronal network activities at the single-neuron level.

Original languageEnglish
Pages (from-to)L1028-L1031
JournalJapanese Journal of Applied Physics, Part 2: Letters
Volume46
Issue number41-44
DOIs
Publication statusPublished - 2007 Nov 9
Externally publishedYes

Keywords

  • 100 kHz sampling
  • Extracellular recording
  • Hippocampal cell
  • Multi-electrode array (MEA)
  • Multisite recording
  • Single neuron
  • Velocity

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy (miscellaneous)
  • Physics and Astronomy(all)

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