On the injectability of free-standing magnetic nanofilms

Silvia Taccola, Virginia Pensabene, Toshinori Fujie, Shinji Takeoka, Nicola M. Pugno, Virgilio Mattoli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Free-standing films with sub-micrometric thickness, composed of soft polymers and functional nanostructures are promising candidates for many potential applications in the biomedical field, such as reduced port abdominal surgery. In this work, freely suspended poly(L-lactic acid) nanofilms with controlled morphology embedding superparamagnetic iron oxide nanoparticles were fabricated by spin-coating deposition. The mechanical properties of magnetic nanofilms were investigated by Strain-Induced Elastic Buckling Instability for Mechanical Measurements (SIEBIMM) test. Our results show that these freely suspended nanocomposite nanofilms are highly flexible and deformable, with Young’s moduli of few GPa. Since they can be handled in liquid with syringes, a quantitative description of the nanofilms behavior during the manipulation with clinically applicable needles has been also provided. These magnetic nanofilms, remotely controllable by external electromagnetic fields, have potential applications in minimally invasive surgery as injectable nanopatches on inner organs wall. [Figure not available: see fulltext.].

Original languageEnglish
Article number51
JournalBiomedical Microdevices
Volume19
Issue number3
DOIs
Publication statusPublished - 2017 Sep 1

Keywords

  • Injectability
  • Magnetic nanocomposite
  • Minimally invasive surgery
  • Nanofilm
  • Nanopatch
  • SIEBIMM

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

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  • Cite this

    Taccola, S., Pensabene, V., Fujie, T., Takeoka, S., Pugno, N. M., & Mattoli, V. (2017). On the injectability of free-standing magnetic nanofilms. Biomedical Microdevices, 19(3), [51]. https://doi.org/10.1007/s10544-017-0192-1