On the mechanical blood trauma

Effect of turbulence

M. V. Kameneva, G. W. Burgreen, K. Kono, J. F. Antaki, B. M. Repko, Mitsuo Umezu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Mechanical blood trauma is still one of the major obstacles in the development of cardiovascular devices. The mechanisms of this blood damage are heterogeneous and are not completely identified. Experimental and computational studies were performed to elucidate the role of turbulent stresses in hemolysis. For the experimental study suspensions of bovine red blood cells (RBCs) in saline or in dextran solution were driven through a closed circulating loop by a centrifugal pump. A small capillary tube with the inner diameter of 1 mm and the length of 50 mm was incorporated into loop with tapered connectors. It was shown that, at the same wall shear stress, the level of hemolysis is significantly higher under turbulent flow conditions than laminar flow conditions. This demonstrated that turbulent stresses contribute strongly to blood trauma. These results concurred with predicted hemolysis by computational fluid dynamics (CFD) modeling of the same blood flow conditions.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Place of PublicationPiscataway, NJ, United States
PublisherIEEE
Pages772
Number of pages1
Volume2
ISBN (Print)0780356756
Publication statusPublished - 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: 1999 Oct 131999 Oct 16

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period99/10/1399/10/16

Fingerprint

Turbulence
Blood
Capillary tubes
Dextran
Centrifugal pumps
Dextrans
Laminar flow
Turbulent flow
Shear stress
Suspensions
Computational fluid dynamics
Cells

ASJC Scopus subject areas

  • Bioengineering

Cite this

Kameneva, M. V., Burgreen, G. W., Kono, K., Antaki, J. F., Repko, B. M., & Umezu, M. (1999). On the mechanical blood trauma: Effect of turbulence. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2, pp. 772). Piscataway, NJ, United States: IEEE.

On the mechanical blood trauma : Effect of turbulence. / Kameneva, M. V.; Burgreen, G. W.; Kono, K.; Antaki, J. F.; Repko, B. M.; Umezu, Mitsuo.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 Piscataway, NJ, United States : IEEE, 1999. p. 772.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kameneva, MV, Burgreen, GW, Kono, K, Antaki, JF, Repko, BM & Umezu, M 1999, On the mechanical blood trauma: Effect of turbulence. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, IEEE, Piscataway, NJ, United States, pp. 772, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 99/10/13.
Kameneva MV, Burgreen GW, Kono K, Antaki JF, Repko BM, Umezu M. On the mechanical blood trauma: Effect of turbulence. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2. Piscataway, NJ, United States: IEEE. 1999. p. 772
Kameneva, M. V. ; Burgreen, G. W. ; Kono, K. ; Antaki, J. F. ; Repko, B. M. ; Umezu, Mitsuo. / On the mechanical blood trauma : Effect of turbulence. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 Piscataway, NJ, United States : IEEE, 1999. pp. 772
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