One month survival with the undulation pump total artificial heart in a goat

Y. Abe, T. Chinzei, T. Isoyama, T. Ono, S. Mochizuki, I. Saito, Kiyotaka Iwasaki, M. Ishimaru, T. Karita, A. Kuono, K. Baba, K. Imachi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The undulation pump is a small continuous flow displacement-type blood pump. The undulation pump to-tal artificial heart (UPTAH) is a unique implantable total artificial heart using undulation pumps. An adult female goat weighing 45.8 kg was used for implantation. The natural heart was replaced with the UPTAH under extracorporal circulation. The cardiac output (CO) was maintained to 100 ml/kg/min by controlling the right pump manually. To prevent lung edema, the left pump was controlled automatically to maintain the left atrial pressure below 20 mm Hg. The CO was maintained for 2 weeks. Thereafter, the CO gradually decreased. The goat suddenly died because of a brain stroke on the 31st postoperative day. At autopsy, the cavity of the left atrial cuff was almost occupied by the big pannus-like thrombus, which was thought to be the cause of death. Improvement of the atrial cuff is necessary to obtain longer survival and is being modified. No thrombus was found inside the pumps. However, temperature rise in a left motor was a problem. Improvement of the efficiency in a motor is necessary. Although many problems still remained, 1 month survival could be obtained with this unique implantable TAH using continuous flow displacement-type blood pumps.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalArtificial Organs
Volume25
Issue number1
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Artificial heart
Artificial Heart
Goats
Cardiac Output
Pumps
Thrombosis
Atrial Pressure
Cause of Death
Autopsy
Edema
Stroke
Lung
Temperature
Brain
Blood
Weighing

Keywords

  • Total artificial heart
  • Undulation pump

ASJC Scopus subject areas

  • Biophysics

Cite this

Abe, Y., Chinzei, T., Isoyama, T., Ono, T., Mochizuki, S., Saito, I., ... Imachi, K. (2001). One month survival with the undulation pump total artificial heart in a goat. Artificial Organs, 25(1), 69-71. https://doi.org/10.1046/j.1525-1594.2001.06655-5.x

One month survival with the undulation pump total artificial heart in a goat. / Abe, Y.; Chinzei, T.; Isoyama, T.; Ono, T.; Mochizuki, S.; Saito, I.; Iwasaki, Kiyotaka; Ishimaru, M.; Karita, T.; Kuono, A.; Baba, K.; Imachi, K.

In: Artificial Organs, Vol. 25, No. 1, 2001, p. 69-71.

Research output: Contribution to journalArticle

Abe, Y, Chinzei, T, Isoyama, T, Ono, T, Mochizuki, S, Saito, I, Iwasaki, K, Ishimaru, M, Karita, T, Kuono, A, Baba, K & Imachi, K 2001, 'One month survival with the undulation pump total artificial heart in a goat', Artificial Organs, vol. 25, no. 1, pp. 69-71. https://doi.org/10.1046/j.1525-1594.2001.06655-5.x
Abe, Y. ; Chinzei, T. ; Isoyama, T. ; Ono, T. ; Mochizuki, S. ; Saito, I. ; Iwasaki, Kiyotaka ; Ishimaru, M. ; Karita, T. ; Kuono, A. ; Baba, K. ; Imachi, K. / One month survival with the undulation pump total artificial heart in a goat. In: Artificial Organs. 2001 ; Vol. 25, No. 1. pp. 69-71.
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