One-pot asymmetric autocatalytic reaction with remarkable amplification of enantiomeric excess

Takanori Shibata, Tadakatsu Hayase, Jun Yamamoto, Kenso Soai

Research output: Contribution to journalArticle

67 Citations (Scopus)


A trace amount (ca. 3 mg) of 2-methylpyrimidyl alkanol with only a slight enantiomeric excess (0.2-0.3% e.e.) was auto-multiplied with dramatic amplification of enantiomeric excess (up to ca. 90% e.e.) in one-pot asymmetric autocatalytic reaction using diisopropylzinc and 2-methylpyrimidine-5-carbaldehyde.

Original languageEnglish
Pages (from-to)1717-1719
Number of pages3
JournalTetrahedron Asymmetry
Issue number11
Publication statusPublished - 1997 Jun 12


ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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