One-pot asymmetric autocatalytic reaction with remarkable amplification of enantiomeric excess

Takanori Shibata, Tadakatsu Hayase, Jun Yamamoto, Kenso Soai

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

A trace amount (ca. 3 mg) of 2-methylpyrimidyl alkanol with only a slight enantiomeric excess (0.2-0.3% e.e.) was auto-multiplied with dramatic amplification of enantiomeric excess (up to ca. 90% e.e.) in one-pot asymmetric autocatalytic reaction using diisopropylzinc and 2-methylpyrimidine-5-carbaldehyde.

Original languageEnglish
Pages (from-to)1717-1719
Number of pages3
JournalTetrahedron Asymmetry
Volume8
Issue number11
DOIs
Publication statusPublished - 1997 Jun 12
Externally publishedYes

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ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

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One-pot asymmetric autocatalytic reaction with remarkable amplification of enantiomeric excess. / Shibata, Takanori; Hayase, Tadakatsu; Yamamoto, Jun; Soai, Kenso.

In: Tetrahedron Asymmetry, Vol. 8, No. 11, 12.06.1997, p. 1717-1719.

Research output: Contribution to journalArticle

Shibata, Takanori ; Hayase, Tadakatsu ; Yamamoto, Jun ; Soai, Kenso. / One-pot asymmetric autocatalytic reaction with remarkable amplification of enantiomeric excess. In: Tetrahedron Asymmetry. 1997 ; Vol. 8, No. 11. pp. 1717-1719.
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