One pot synthesis of haloacetylenes from trimethylsilylacetylenes

Toshio Nishikawa, Satoshi Shibuya, Seijiro Hosokawa, Minoru Isobe

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

An efficient and convenient method for one step conversion of trimethylsilylacetylenes into haloacetylenes has been developed. This method is sufficiently mild to apply a variety of substrates having many kinds of functional group. The validity of this method is demonstrated in the synthesis of simple model compound of esperamicin/calicheamicin aglycon.

Original languageEnglish
Pages (from-to)485-486
Number of pages2
JournalSynlett
Volume1994
Issue number7
DOIs
Publication statusPublished - 1994 Jul 1
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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