One-step synthesis of ethyl quinaldates by lewis acid catalyzed three-component coupling reaction of aromatic amines, aliphatic aldehydes and ethyl glyoxylate

Takashi Inada, Takayuki Nakajima, Isao Shimizu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A convenient, efficient and simple one-pot method for the synthesis of quinaldates was developed by three-component coupling reaction of an arylamine (1), ethyl glyoxylate and an aliphatic aldehyde (2) in the presence of Lewis acid catalyst. The reaction proceeded most effectively using Yb(OTf)3 as a catalyst.

Original languageEnglish
Pages (from-to)611-619
Number of pages9
JournalHeterocycles
Volume66
Issue number1
DOIs
Publication statusPublished - 2005 Dec 31

ASJC Scopus subject areas

  • Organic Chemistry

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