Ontogenesis of glucose sensitivity in the rat lateral hypothalamus: a brain slice study

Shigenobu Shibata, Yutaka Oomura, Hitoshi Kita

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The development of glucose-sensitive neurons in the lateral hypothalamus (LHA) brain slices was examined. In 60-100-day-old rats, 20% of LHA neurons were sensitive, that is, their firing rates decreased upon increase in the glucose concentration in the perfusate and increased upon decrease in glucose concentration. In 2-, 3- and 7-day-old rats, 16% of the neurons were glucose sensitive. Results confirm glucose-sensitivity in the LHA at a very early stage of ontogeny.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalDevelopmental Brain Research
Issue number1
Publication statusPublished - 1982 Sep



  • brain slice
  • glucose-sensitive neuron
  • lateral hypothalamic area
  • ontogeny
  • rat

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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