Abstract
Knowledge of life has expanded dramatically during the twentieth century and has produced the modern disciplines of genomics and proteomics. However, there remains the great challenge of discovering the integration and regulation of these living components in time and space within the cell. As we move into the postgenomic period, the complementarity between genomics and proteomics will become apparent, and the connections between them will be exploited, although, neither genomics, proteomics, nor, for that matter, their simple combination will provide the data necessary to interconnect molecular events in living cells in time and space. e cells in a group are dierent entities. Each of them respond to the perturbations dierently (Spudich and Koshland 1976). e dierences between cells arise even among those grown in homogeneous conditions and considered to have identical genetic information. Why and how do these dierences arise? ey might be caused by several factors like unequal distributions of biomolecules in cells, mutations, interactions between cells, and uctuations of environmental elements. A system that can observe interactions between specic cells continuously under fully controlled.
| Original language | English |
|---|---|
| Title of host publication | Biomedical Photonics Handbook, Second Edition |
| Subtitle of host publication | Therapeutics and Advanced Biophotonics |
| Publisher | CRC Press |
| Pages | 457-491 |
| Number of pages | 35 |
| ISBN (Electronic) | 9781420085174 |
| ISBN (Print) | 9781420085167 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Physics and Astronomy(all)
- Engineering(all)
Cite this
Optical trapping techniques in bioanalysis. / Yasuda, Kenji.
Biomedical Photonics Handbook, Second Edition: Therapeutics and Advanced Biophotonics. CRC Press, 2014. p. 457-491.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Optical trapping techniques in bioanalysis
AU - Yasuda, Kenji
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Knowledge of life has expanded dramatically during the twentieth century and has produced the modern disciplines of genomics and proteomics. However, there remains the great challenge of discovering the integration and regulation of these living components in time and space within the cell. As we move into the postgenomic period, the complementarity between genomics and proteomics will become apparent, and the connections between them will be exploited, although, neither genomics, proteomics, nor, for that matter, their simple combination will provide the data necessary to interconnect molecular events in living cells in time and space. e cells in a group are dierent entities. Each of them respond to the perturbations dierently (Spudich and Koshland 1976). e dierences between cells arise even among those grown in homogeneous conditions and considered to have identical genetic information. Why and how do these dierences arise? ey might be caused by several factors like unequal distributions of biomolecules in cells, mutations, interactions between cells, and uctuations of environmental elements. A system that can observe interactions between specic cells continuously under fully controlled.
AB - Knowledge of life has expanded dramatically during the twentieth century and has produced the modern disciplines of genomics and proteomics. However, there remains the great challenge of discovering the integration and regulation of these living components in time and space within the cell. As we move into the postgenomic period, the complementarity between genomics and proteomics will become apparent, and the connections between them will be exploited, although, neither genomics, proteomics, nor, for that matter, their simple combination will provide the data necessary to interconnect molecular events in living cells in time and space. e cells in a group are dierent entities. Each of them respond to the perturbations dierently (Spudich and Koshland 1976). e dierences between cells arise even among those grown in homogeneous conditions and considered to have identical genetic information. Why and how do these dierences arise? ey might be caused by several factors like unequal distributions of biomolecules in cells, mutations, interactions between cells, and uctuations of environmental elements. A system that can observe interactions between specic cells continuously under fully controlled.
UR - http://www.scopus.com/inward/record.url?scp=85054615584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054615584&partnerID=8YFLogxK
U2 - 10.1201/b17288
DO - 10.1201/b17288
M3 - Chapter
AN - SCOPUS:85054615584
SN - 9781420085167
SP - 457
EP - 491
BT - Biomedical Photonics Handbook, Second Edition
PB - CRC Press
ER -