TY - JOUR
T1 - Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel 1H-MRS at 1.5 T
AU - Chernov, Mikhail F.
AU - Muragaki, Yoshihiro
AU - Maruyama, Takashi
AU - Ono, Yuko
AU - Usukura, Masao
AU - Yoshida, Shigetoshi
AU - Nakamura, Ryoichi
AU - Iseki, Hiroshi
AU - Kubo, Osami
AU - Hori, Tomokatsu
AU - Takakura, Kintomo
N1 - Funding Information:
Acknowledgements This work was supported by the Program for Promoting the Establishment of Strategic Research Centers, Special Coordination Funds for Promoting Science and Technology, Ministry of Education, Culture, Sports, Science, and Technology (Japan).
PY - 2009/3
Y1 - 2009/3
N2 - Introduction: The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ( 1H-MRS). Materials and methods: Thirty patients (22 men and eight women; mean age 38∈±∈15 years) with suspicious intracranial gliomas underwent single-voxel long-echo (TR 2,000 ms, TE 136 ms, 128-256 acquisitions) 1H-MRS of the tumor, peritumoral brain tissue, and distant normal-appearing white matter before and several hours (median, 3 h; range, 1.2-3.7 h) after ingestion of choline with prescribed dose of 50 mg/kg (median actual dose, 52 mg/kg; range, 48-78 mg/kg). Investigations were done using 1.5 T clinical magnetic resonance imager. The volume of the rectangular 1H-MRS voxel was either 3.4 or 8 cm3. At the time of both spectroscopic examinations, similar voxels' positioning and size and technical parameters of 1H-MRS were used. Surgery was done in 27 patients within 1 to 68 days thereafter. In all cases, more than 80% resection of the neoplasm was attained. Results: There were 12 low-grade gliomas and 15 high-grade gliomas. MIB-1 index varied from 0% to 51.7% (median, 13.8%). Statistical analysis did not disclose significant differences of any investigated metabolic parameter of the tumor, peritumoral brain tissue and distant normal-appearing white matter between two spectroscopic examinations. Conclusion: Single-voxel 1H-MRS at 1.5 T could not detect significant changes of the metabolic characteristics of gliomas, peritumoral brain tissue, and distant normal-appearing white matter after oral administration of choline.
AB - Introduction: The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ( 1H-MRS). Materials and methods: Thirty patients (22 men and eight women; mean age 38∈±∈15 years) with suspicious intracranial gliomas underwent single-voxel long-echo (TR 2,000 ms, TE 136 ms, 128-256 acquisitions) 1H-MRS of the tumor, peritumoral brain tissue, and distant normal-appearing white matter before and several hours (median, 3 h; range, 1.2-3.7 h) after ingestion of choline with prescribed dose of 50 mg/kg (median actual dose, 52 mg/kg; range, 48-78 mg/kg). Investigations were done using 1.5 T clinical magnetic resonance imager. The volume of the rectangular 1H-MRS voxel was either 3.4 or 8 cm3. At the time of both spectroscopic examinations, similar voxels' positioning and size and technical parameters of 1H-MRS were used. Surgery was done in 27 patients within 1 to 68 days thereafter. In all cases, more than 80% resection of the neoplasm was attained. Results: There were 12 low-grade gliomas and 15 high-grade gliomas. MIB-1 index varied from 0% to 51.7% (median, 13.8%). Statistical analysis did not disclose significant differences of any investigated metabolic parameter of the tumor, peritumoral brain tissue and distant normal-appearing white matter between two spectroscopic examinations. Conclusion: Single-voxel 1H-MRS at 1.5 T could not detect significant changes of the metabolic characteristics of gliomas, peritumoral brain tissue, and distant normal-appearing white matter after oral administration of choline.
KW - Brain
KW - Choline ingestion
KW - Choline metabolism
KW - Glioma
KW - Proton magnetic resonance spectroscopy
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U2 - 10.1007/s00234-008-0471-x
DO - 10.1007/s00234-008-0471-x
M3 - Article
C2 - 18949472
AN - SCOPUS:60449113598
SN - 0028-3940
VL - 51
SP - 137
EP - 143
JO - Neuroradiology
JF - Neuroradiology
IS - 3
ER -