Abstract
Introduction: The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ( 1H-MRS). Materials and methods: Thirty patients (22 men and eight women; mean age 38∈±∈15 years) with suspicious intracranial gliomas underwent single-voxel long-echo (TR 2,000 ms, TE 136 ms, 128-256 acquisitions) 1H-MRS of the tumor, peritumoral brain tissue, and distant normal-appearing white matter before and several hours (median, 3 h; range, 1.2-3.7 h) after ingestion of choline with prescribed dose of 50 mg/kg (median actual dose, 52 mg/kg; range, 48-78 mg/kg). Investigations were done using 1.5 T clinical magnetic resonance imager. The volume of the rectangular 1H-MRS voxel was either 3.4 or 8 cm3. At the time of both spectroscopic examinations, similar voxels' positioning and size and technical parameters of 1H-MRS were used. Surgery was done in 27 patients within 1 to 68 days thereafter. In all cases, more than 80% resection of the neoplasm was attained. Results: There were 12 low-grade gliomas and 15 high-grade gliomas. MIB-1 index varied from 0% to 51.7% (median, 13.8%). Statistical analysis did not disclose significant differences of any investigated metabolic parameter of the tumor, peritumoral brain tissue and distant normal-appearing white matter between two spectroscopic examinations. Conclusion: Single-voxel 1H-MRS at 1.5 T could not detect significant changes of the metabolic characteristics of gliomas, peritumoral brain tissue, and distant normal-appearing white matter after oral administration of choline.
| Original language | English |
|---|---|
| Pages (from-to) | 137-143 |
| Number of pages | 7 |
| Journal | Neuroradiology |
| Volume | 51 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2009 Mar |
| Externally published | Yes |
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Keywords
- Brain
- Choline ingestion
- Choline metabolism
- Glioma
- Proton magnetic resonance spectroscopy
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
Cite this
Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel 1H-MRS at 1.5 T. / Chernov, Mikhail F.; Muragaki, Yoshihiro; Maruyama, Takashi; Ono, Yuko; Usukura, Masao; Yoshida, Shigetoshi; Nakamura, Ryoichi; Iseki, Hiroshi; Kubo, Osami; Hori, Tomokatsu; Takakura, Kintomo.
In: Neuroradiology, Vol. 51, No. 3, 03.2009, p. 137-143.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel 1H-MRS at 1.5 T
AU - Chernov, Mikhail F.
AU - Muragaki, Yoshihiro
AU - Maruyama, Takashi
AU - Ono, Yuko
AU - Usukura, Masao
AU - Yoshida, Shigetoshi
AU - Nakamura, Ryoichi
AU - Iseki, Hiroshi
AU - Kubo, Osami
AU - Hori, Tomokatsu
AU - Takakura, Kintomo
PY - 2009/3
Y1 - 2009/3
N2 - Introduction: The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ( 1H-MRS). Materials and methods: Thirty patients (22 men and eight women; mean age 38∈±∈15 years) with suspicious intracranial gliomas underwent single-voxel long-echo (TR 2,000 ms, TE 136 ms, 128-256 acquisitions) 1H-MRS of the tumor, peritumoral brain tissue, and distant normal-appearing white matter before and several hours (median, 3 h; range, 1.2-3.7 h) after ingestion of choline with prescribed dose of 50 mg/kg (median actual dose, 52 mg/kg; range, 48-78 mg/kg). Investigations were done using 1.5 T clinical magnetic resonance imager. The volume of the rectangular 1H-MRS voxel was either 3.4 or 8 cm3. At the time of both spectroscopic examinations, similar voxels' positioning and size and technical parameters of 1H-MRS were used. Surgery was done in 27 patients within 1 to 68 days thereafter. In all cases, more than 80% resection of the neoplasm was attained. Results: There were 12 low-grade gliomas and 15 high-grade gliomas. MIB-1 index varied from 0% to 51.7% (median, 13.8%). Statistical analysis did not disclose significant differences of any investigated metabolic parameter of the tumor, peritumoral brain tissue and distant normal-appearing white matter between two spectroscopic examinations. Conclusion: Single-voxel 1H-MRS at 1.5 T could not detect significant changes of the metabolic characteristics of gliomas, peritumoral brain tissue, and distant normal-appearing white matter after oral administration of choline.
AB - Introduction: The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ( 1H-MRS). Materials and methods: Thirty patients (22 men and eight women; mean age 38∈±∈15 years) with suspicious intracranial gliomas underwent single-voxel long-echo (TR 2,000 ms, TE 136 ms, 128-256 acquisitions) 1H-MRS of the tumor, peritumoral brain tissue, and distant normal-appearing white matter before and several hours (median, 3 h; range, 1.2-3.7 h) after ingestion of choline with prescribed dose of 50 mg/kg (median actual dose, 52 mg/kg; range, 48-78 mg/kg). Investigations were done using 1.5 T clinical magnetic resonance imager. The volume of the rectangular 1H-MRS voxel was either 3.4 or 8 cm3. At the time of both spectroscopic examinations, similar voxels' positioning and size and technical parameters of 1H-MRS were used. Surgery was done in 27 patients within 1 to 68 days thereafter. In all cases, more than 80% resection of the neoplasm was attained. Results: There were 12 low-grade gliomas and 15 high-grade gliomas. MIB-1 index varied from 0% to 51.7% (median, 13.8%). Statistical analysis did not disclose significant differences of any investigated metabolic parameter of the tumor, peritumoral brain tissue and distant normal-appearing white matter between two spectroscopic examinations. Conclusion: Single-voxel 1H-MRS at 1.5 T could not detect significant changes of the metabolic characteristics of gliomas, peritumoral brain tissue, and distant normal-appearing white matter after oral administration of choline.
KW - Brain
KW - Choline ingestion
KW - Choline metabolism
KW - Glioma
KW - Proton magnetic resonance spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=60449113598&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=60449113598&partnerID=8YFLogxK
U2 - 10.1007/s00234-008-0471-x
DO - 10.1007/s00234-008-0471-x
M3 - Article
C2 - 18949472
AN - SCOPUS:60449113598
VL - 51
SP - 137
EP - 143
JO - Neuroradiology
JF - Neuroradiology
SN - 0028-3940
IS - 3
ER -