Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel 1H-MRS at 1.5 T

Mikhail F. Chernov, Yoshihiro Muragaki, Takashi Maruyama, Yuko Ono, Masao Usukura, Shigetoshi Yoshida, Ryoichi Nakamura, Hiroshi Iseki, Osami Kubo, Tomokatsu Hori, Kintomo Takakura

Research output: Contribution to journalArticle

Abstract

Introduction: The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ( 1H-MRS). Materials and methods: Thirty patients (22 men and eight women; mean age 38∈±∈15 years) with suspicious intracranial gliomas underwent single-voxel long-echo (TR 2,000 ms, TE 136 ms, 128-256 acquisitions) 1H-MRS of the tumor, peritumoral brain tissue, and distant normal-appearing white matter before and several hours (median, 3 h; range, 1.2-3.7 h) after ingestion of choline with prescribed dose of 50 mg/kg (median actual dose, 52 mg/kg; range, 48-78 mg/kg). Investigations were done using 1.5 T clinical magnetic resonance imager. The volume of the rectangular 1H-MRS voxel was either 3.4 or 8 cm3. At the time of both spectroscopic examinations, similar voxels' positioning and size and technical parameters of 1H-MRS were used. Surgery was done in 27 patients within 1 to 68 days thereafter. In all cases, more than 80% resection of the neoplasm was attained. Results: There were 12 low-grade gliomas and 15 high-grade gliomas. MIB-1 index varied from 0% to 51.7% (median, 13.8%). Statistical analysis did not disclose significant differences of any investigated metabolic parameter of the tumor, peritumoral brain tissue and distant normal-appearing white matter between two spectroscopic examinations. Conclusion: Single-voxel 1H-MRS at 1.5 T could not detect significant changes of the metabolic characteristics of gliomas, peritumoral brain tissue, and distant normal-appearing white matter after oral administration of choline.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalNeuroradiology
Volume51
Issue number3
DOIs
Publication statusPublished - 2009 Mar
Externally publishedYes

Fingerprint

Choline
Glioma
Oral Administration
Brain Neoplasms
White Matter
Proton Magnetic Resonance Spectroscopy
Magnetic Resonance Spectroscopy
Eating
Brain
Neoplasms

Keywords

  • Brain
  • Choline ingestion
  • Choline metabolism
  • Glioma
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel 1H-MRS at 1.5 T. / Chernov, Mikhail F.; Muragaki, Yoshihiro; Maruyama, Takashi; Ono, Yuko; Usukura, Masao; Yoshida, Shigetoshi; Nakamura, Ryoichi; Iseki, Hiroshi; Kubo, Osami; Hori, Tomokatsu; Takakura, Kintomo.

In: Neuroradiology, Vol. 51, No. 3, 03.2009, p. 137-143.

Research output: Contribution to journalArticle

Chernov, MF, Muragaki, Y, Maruyama, T, Ono, Y, Usukura, M, Yoshida, S, Nakamura, R, Iseki, H, Kubo, O, Hori, T & Takakura, K 2009, 'Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel 1H-MRS at 1.5 T', Neuroradiology, vol. 51, no. 3, pp. 137-143. https://doi.org/10.1007/s00234-008-0471-x
Chernov, Mikhail F. ; Muragaki, Yoshihiro ; Maruyama, Takashi ; Ono, Yuko ; Usukura, Masao ; Yoshida, Shigetoshi ; Nakamura, Ryoichi ; Iseki, Hiroshi ; Kubo, Osami ; Hori, Tomokatsu ; Takakura, Kintomo. / Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel 1H-MRS at 1.5 T. In: Neuroradiology. 2009 ; Vol. 51, No. 3. pp. 137-143.
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title = "Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel 1H-MRS at 1.5 T",
abstract = "Introduction: The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ( 1H-MRS). Materials and methods: Thirty patients (22 men and eight women; mean age 38∈±∈15 years) with suspicious intracranial gliomas underwent single-voxel long-echo (TR 2,000 ms, TE 136 ms, 128-256 acquisitions) 1H-MRS of the tumor, peritumoral brain tissue, and distant normal-appearing white matter before and several hours (median, 3 h; range, 1.2-3.7 h) after ingestion of choline with prescribed dose of 50 mg/kg (median actual dose, 52 mg/kg; range, 48-78 mg/kg). Investigations were done using 1.5 T clinical magnetic resonance imager. The volume of the rectangular 1H-MRS voxel was either 3.4 or 8 cm3. At the time of both spectroscopic examinations, similar voxels' positioning and size and technical parameters of 1H-MRS were used. Surgery was done in 27 patients within 1 to 68 days thereafter. In all cases, more than 80{\%} resection of the neoplasm was attained. Results: There were 12 low-grade gliomas and 15 high-grade gliomas. MIB-1 index varied from 0{\%} to 51.7{\%} (median, 13.8{\%}). Statistical analysis did not disclose significant differences of any investigated metabolic parameter of the tumor, peritumoral brain tissue and distant normal-appearing white matter between two spectroscopic examinations. Conclusion: Single-voxel 1H-MRS at 1.5 T could not detect significant changes of the metabolic characteristics of gliomas, peritumoral brain tissue, and distant normal-appearing white matter after oral administration of choline.",
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T1 - Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel 1H-MRS at 1.5 T

AU - Chernov, Mikhail F.

AU - Muragaki, Yoshihiro

AU - Maruyama, Takashi

AU - Ono, Yuko

AU - Usukura, Masao

AU - Yoshida, Shigetoshi

AU - Nakamura, Ryoichi

AU - Iseki, Hiroshi

AU - Kubo, Osami

AU - Hori, Tomokatsu

AU - Takakura, Kintomo

PY - 2009/3

Y1 - 2009/3

N2 - Introduction: The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ( 1H-MRS). Materials and methods: Thirty patients (22 men and eight women; mean age 38∈±∈15 years) with suspicious intracranial gliomas underwent single-voxel long-echo (TR 2,000 ms, TE 136 ms, 128-256 acquisitions) 1H-MRS of the tumor, peritumoral brain tissue, and distant normal-appearing white matter before and several hours (median, 3 h; range, 1.2-3.7 h) after ingestion of choline with prescribed dose of 50 mg/kg (median actual dose, 52 mg/kg; range, 48-78 mg/kg). Investigations were done using 1.5 T clinical magnetic resonance imager. The volume of the rectangular 1H-MRS voxel was either 3.4 or 8 cm3. At the time of both spectroscopic examinations, similar voxels' positioning and size and technical parameters of 1H-MRS were used. Surgery was done in 27 patients within 1 to 68 days thereafter. In all cases, more than 80% resection of the neoplasm was attained. Results: There were 12 low-grade gliomas and 15 high-grade gliomas. MIB-1 index varied from 0% to 51.7% (median, 13.8%). Statistical analysis did not disclose significant differences of any investigated metabolic parameter of the tumor, peritumoral brain tissue and distant normal-appearing white matter between two spectroscopic examinations. Conclusion: Single-voxel 1H-MRS at 1.5 T could not detect significant changes of the metabolic characteristics of gliomas, peritumoral brain tissue, and distant normal-appearing white matter after oral administration of choline.

AB - Introduction: The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ( 1H-MRS). Materials and methods: Thirty patients (22 men and eight women; mean age 38∈±∈15 years) with suspicious intracranial gliomas underwent single-voxel long-echo (TR 2,000 ms, TE 136 ms, 128-256 acquisitions) 1H-MRS of the tumor, peritumoral brain tissue, and distant normal-appearing white matter before and several hours (median, 3 h; range, 1.2-3.7 h) after ingestion of choline with prescribed dose of 50 mg/kg (median actual dose, 52 mg/kg; range, 48-78 mg/kg). Investigations were done using 1.5 T clinical magnetic resonance imager. The volume of the rectangular 1H-MRS voxel was either 3.4 or 8 cm3. At the time of both spectroscopic examinations, similar voxels' positioning and size and technical parameters of 1H-MRS were used. Surgery was done in 27 patients within 1 to 68 days thereafter. In all cases, more than 80% resection of the neoplasm was attained. Results: There were 12 low-grade gliomas and 15 high-grade gliomas. MIB-1 index varied from 0% to 51.7% (median, 13.8%). Statistical analysis did not disclose significant differences of any investigated metabolic parameter of the tumor, peritumoral brain tissue and distant normal-appearing white matter between two spectroscopic examinations. Conclusion: Single-voxel 1H-MRS at 1.5 T could not detect significant changes of the metabolic characteristics of gliomas, peritumoral brain tissue, and distant normal-appearing white matter after oral administration of choline.

KW - Brain

KW - Choline ingestion

KW - Choline metabolism

KW - Glioma

KW - Proton magnetic resonance spectroscopy

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