Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel 1H-MRS at 1.5 T

Mikhail F. Chernov, Yoshihiro Muragaki, Takashi Maruyama, Yuko Ono, Masao Usukura, Shigetoshi Yoshida, Ryoichi Nakamura, Hiroshi Iseki, Osami Kubo, Tomokatsu Hori, Kintomo Takakura

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    Abstract

    Introduction: The present study was done for evaluation of the possible influence of the oral administration of choline on metabolic characteristics of gliomas detected with proton magnetic resonance spectroscopy ( 1H-MRS). Materials and methods: Thirty patients (22 men and eight women; mean age 38∈±∈15 years) with suspicious intracranial gliomas underwent single-voxel long-echo (TR 2,000 ms, TE 136 ms, 128-256 acquisitions) 1H-MRS of the tumor, peritumoral brain tissue, and distant normal-appearing white matter before and several hours (median, 3 h; range, 1.2-3.7 h) after ingestion of choline with prescribed dose of 50 mg/kg (median actual dose, 52 mg/kg; range, 48-78 mg/kg). Investigations were done using 1.5 T clinical magnetic resonance imager. The volume of the rectangular 1H-MRS voxel was either 3.4 or 8 cm3. At the time of both spectroscopic examinations, similar voxels' positioning and size and technical parameters of 1H-MRS were used. Surgery was done in 27 patients within 1 to 68 days thereafter. In all cases, more than 80% resection of the neoplasm was attained. Results: There were 12 low-grade gliomas and 15 high-grade gliomas. MIB-1 index varied from 0% to 51.7% (median, 13.8%). Statistical analysis did not disclose significant differences of any investigated metabolic parameter of the tumor, peritumoral brain tissue and distant normal-appearing white matter between two spectroscopic examinations. Conclusion: Single-voxel 1H-MRS at 1.5 T could not detect significant changes of the metabolic characteristics of gliomas, peritumoral brain tissue, and distant normal-appearing white matter after oral administration of choline.

    Original languageEnglish
    Pages (from-to)137-143
    Number of pages7
    JournalNeuroradiology
    Volume51
    Issue number3
    DOIs
    Publication statusPublished - 2009 Mar 1

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    Keywords

    • Brain
    • Choline ingestion
    • Choline metabolism
    • Glioma
    • Proton magnetic resonance spectroscopy

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Clinical Neurology
    • Cardiology and Cardiovascular Medicine

    Cite this

    Chernov, M. F., Muragaki, Y., Maruyama, T., Ono, Y., Usukura, M., Yoshida, S., Nakamura, R., Iseki, H., Kubo, O., Hori, T., & Takakura, K. (2009). Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel 1H-MRS at 1.5 T. Neuroradiology, 51(3), 137-143. https://doi.org/10.1007/s00234-008-0471-x