Orchestrated electrostatic interactions among myosin, actin, ATP, and water

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1 Citation (Scopus)

    Abstract

    The electrostatic interactions are deeply involved in the force-generating function of the actomyosin molecular motor where myosin, actin, ATP, and water are interacting with each other in a orchestrated manner. In this chapter, an electrostatic perspective is presented based on our recent molecular dynamics simulation studies on the force-generation mechanisms of the actomyosin molecular motor. First, as an unusual property of the electrostatic interaction in water, thermodynamics of association between oppositely singed charges is addressed. Then, our computational results regarding the electrostatic interaction between myosin and actin are described, featuring a sawtooth-like asymmetric energy landscape on which myosin generates forces by multiple mechanisms including the Brownian ratchet-like mechanism. Then the role of ATP is discussed, with a focus on "dielectric allostery" that we found in myosin as an allosteric response to the ATP binding, which serves as weakening the actin-myosin electrostatic interaction and causes myosin to dissociate from actin. Finally, the role of water is discussed from the viewpoint of the association thermodynamics of biomolecules.

    Original languageEnglish
    Title of host publicationThe Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery
    PublisherSpringer Singapore
    Pages113-122
    Number of pages10
    ISBN (Electronic)9789811084591
    ISBN (Print)9789811084584
    DOIs
    Publication statusPublished - 2018 May 7

    Fingerprint

    Myosins
    Coulomb interactions
    Static Electricity
    Water
    Actins
    Actomyosin
    Thermodynamics
    Adenosine Triphosphate
    Association reactions
    Biomolecules
    Molecular Dynamics Simulation
    Molecular dynamics
    ATP-G-actin
    Electrostatics
    Computer simulation

    ASJC Scopus subject areas

    • Chemistry(all)
    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Takano, M. (2018). Orchestrated electrostatic interactions among myosin, actin, ATP, and water. In The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery (pp. 113-122). Springer Singapore. https://doi.org/10.1007/978-981-10-8459-1_8

    Orchestrated electrostatic interactions among myosin, actin, ATP, and water. / Takano, Mitsunori.

    The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery. Springer Singapore, 2018. p. 113-122.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Takano, M 2018, Orchestrated electrostatic interactions among myosin, actin, ATP, and water. in The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery. Springer Singapore, pp. 113-122. https://doi.org/10.1007/978-981-10-8459-1_8
    Takano M. Orchestrated electrostatic interactions among myosin, actin, ATP, and water. In The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery. Springer Singapore. 2018. p. 113-122 https://doi.org/10.1007/978-981-10-8459-1_8
    Takano, Mitsunori. / Orchestrated electrostatic interactions among myosin, actin, ATP, and water. The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery. Springer Singapore, 2018. pp. 113-122
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