Orchestrated electrostatic interactions among myosin, actin, ATP, and water

Mitsunori Takano

doi:10.1007/978-981-10-8459-1_8

Orchestrated electrostatic interactions among myosin, actin, ATP, and water

Mitsunori Takano

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

The electrostatic interactions are deeply involved in the force-generating function of the actomyosin molecular motor where myosin, actin, ATP, and water are interacting with each other in a orchestrated manner. In this chapter, an electrostatic perspective is presented based on our recent molecular dynamics simulation studies on the force-generation mechanisms of the actomyosin molecular motor. First, as an unusual property of the electrostatic interaction in water, thermodynamics of association between oppositely singed charges is addressed. Then, our computational results regarding the electrostatic interaction between myosin and actin are described, featuring a sawtooth-like asymmetric energy landscape on which myosin generates forces by multiple mechanisms including the Brownian ratchet-like mechanism. Then the role of ATP is discussed, with a focus on "dielectric allostery" that we found in myosin as an allosteric response to the ATP binding, which serves as weakening the actin-myosin electrostatic interaction and causes myosin to dissociate from actin. Finally, the role of water is discussed from the viewpoint of the association thermodynamics of biomolecules.

Original language	English
Title of host publication	The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery
Publisher	Springer Singapore
Pages	113-122
Number of pages	10
ISBN (Electronic)	9789811084591
ISBN (Print)	9789811084584
DOIs	https://doi.org/10.1007/978-981-10-8459-1_8
Publication status	Published - 2018 May 7

Fingerprint

Myosins

Coulomb interactions

Static Electricity

Water

Actins

Actomyosin

Thermodynamics

Adenosine Triphosphate

Association reactions

Biomolecules

Molecular Dynamics Simulation

Molecular dynamics

ATP-G-actin

Electrostatics

Computer simulation

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)

Cite this

Takano, M. (2018). Orchestrated electrostatic interactions among myosin, actin, ATP, and water. In The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery (pp. 113-122). Springer Singapore. https://doi.org/10.1007/978-981-10-8459-1_8

Orchestrated electrostatic interactions among myosin, actin, ATP, and water. / Takano, Mitsunori.

The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery. Springer Singapore, 2018. p. 113-122.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Takano, M 2018, Orchestrated electrostatic interactions among myosin, actin, ATP, and water. in The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery. Springer Singapore, pp. 113-122. https://doi.org/10.1007/978-981-10-8459-1_8

Takano M. Orchestrated electrostatic interactions among myosin, actin, ATP, and water. In The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery. Springer Singapore. 2018. p. 113-122 https://doi.org/10.1007/978-981-10-8459-1_8

Takano, Mitsunori. / Orchestrated electrostatic interactions among myosin, actin, ATP, and water. The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery. Springer Singapore, 2018. pp. 113-122

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Access to Document

10.1007/978-981-10-8459-1_8