Orexigenic/anorexigenic signals in Bulimia nervosa

Yoshiyuki Takimoto, Akio Inui, Hiroaki Kumano, Tomifusa Kuboki

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Bulimia nervosa (BN) and Anorexia Nervosa (AN) are currently classified as eating disorders (ED). Both disorders are the product of complex interaction between physiological and psychological and social processes; they are characterized by abnormal eating behavior. However, patients with BN differ from AN in their nutritional state and response of treatment with serotonin-selective reuptake inhibitor (SSRI) as well as frequency of comorbidity of mood and anxiety disorders. Although biological mechanisms of both BN and AN are largely unknown, excess of both feeding-stimulatory and feeding inhibitory signaling in AN have been indicated. This report reviews data that point to the hypothesis that dysregulation of monoaminergic and new peptidergic circuitry controlling food intake and energy expenditure play a major role in the eating behavior of BN.

Original languageEnglish
Pages (from-to)349-360
Number of pages12
JournalCurrent Molecular Medicine
Volume3
Issue number4
DOIs
Publication statusPublished - 2003 Jun 1

Keywords

  • Bulimia nervosa
  • Eating disorder
  • Monoamine
  • Neuropeptide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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